◀ Back to PCNA

INS — PCNA

Text-mined interactions from Literome

Pagès et al., J Biol Chem 1999 : Consequently, a decrease of p27(Kip1)-cdk2 association, an inhibition of insulin induced cyclin E-cdk2 kinase activity, and an accumulation of hypophosphorylated retinoblastoma gene product ( Rb ) were observed
de la Monte et al., Alcohol Clin Exp Res 1999 : This study explores the roles of the Grb2- and Syp binding motifs of IRS-1 in relation to the inhibitory effects of ethanol on insulin stimulated DNA synthesis, proliferating cell nuclear antigen ( PCNA ) and glyceraldehyde 3-phosphate dehydrogenase ( GAPDH ) expression, and activation of mitogen activated protein kinase ( MAPK ), which is known to be essential for cell proliferation ... Ethanol exposure decreased insulin stimulated DNA synthesis, PCNA , GAPDH, and activated MAPK levels in all clones, but the wild-type IRS-1 transfectants were relatively resistant, and the IRS-1deltaGrb2 transfectants were extraordinarily sensitive to these inhibitory effects of ethanol ... The findings suggest that insulin stimulated DNA synthesis and PCNA expression are mediated through the Syp binding domain, whereas GAPDH expression and MAPK activation are modulated through both the Grb2 and Syp motifs of IRS-1
Van Keymeulen et al., Oncogene 1999 : Cyclin D3 accumulation and activity were differentially regulated by insulin and TSH, which points out this cyclin as an integrator that ranks these comitogenic pathways as supportive and activatory, respectively
Wei et al., Nat Med 2005 : Here we show that inhibition of the activity of cyclin dependent kinase 5 (Cdk5) enhanced insulin secretion under conditions of stimulation by high glucose but not low glucose in MIN6 cells and pancreatic islets
Okada et al., J Biol Chem 2008 : Insulin stimulation results in the activation of cyclin dependent kinase-5 (CDK5) in lipid raft domains via a Fyn dependent phosphorylation on tyrosine residue 15
Palaniappan et al., Mol Cell Endocrinol 2013 : Furthermore, insulin stimulated T-I cell proliferation and the expression of cell cycle regulatory proteins CDK4, CCND3 and PCNA were also blocked by rapamycin
Tang et al., Endocrinology 1995 : In addition, the ability of insulin to induce cyclin D expression was reduced by GH ... The regulatory effects of GH and insulin are mediated at least in part by the alternating expression of cyclin D protein
Sutherland et al., J Steroid Biochem Mol Biol 1993 (Breast Neoplasms) : Following growth arrest of T-47D breast cancer cells by serum deprivation restimulation with insulin results in sequential induction of cyclin genes
Lee et al., Biochem Biophys Res Commun 1998 : Synergistic effect of cyclic AMP and insulin on the expression of cyclin A gene in Swiss 3T3 cells