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FAS — IL6
Text-mined interactions from Literome
Mouawad et al., Cytokines Cell Mol Ther 2000
(Melanoma) :
Effect of endogenous
interleukin-6 on
Fas ( APO-1/CD95 ) receptor expression in advanced melanoma patients
Choi et al., J Neurooncol 2002
(Astrocytoma...) :
Fas engagement
increases expression of
interleukin-6 in human glioma cells
Perl et al., Am J Pathol 2005
(Disease Models, Animal...) :
Only
Fas-siRNA markedly
diminished lung tissue tumor necrosis factor-alpha,
IL-6 , IL-10, interferon-gamma, IL-12, and caspase-3 activity
Graf et al., Arch Biochem Biophys 2008
:
The present study characterizes the molecular mechanisms of
CD95L induced inhibition of
IL-6 signaling, which is known to mediate hepatoprotective effects in response to various toxins
Guazzone et al., Microsc Res Tech 2009
(Inflammation...) :
Germ cells expressing TNFR1,
IL-6R , and
Fas increase in number and undergo apoptosis, through the TNF-alpha/TNFR1, IL-6/IL-6R, and Fas/Fas L systems
Fluhr et al., Mol Hum Reprod 2011
:
In contrast,
IL-6 , MCP-1 and RANTES were not
regulated by
Fas
Hu et al., Mol Med Report 2008
:
SOCS1 silencing in DCs could prevent immune tolerance by inhibiting
Fas and Fas-L expression,
induced by an increase in IL-12p70 and
IL-6 production
Cesaratto et al., PloS one 2013
:
E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced
IL-6 and IL-8 expression
induced by TNF-a and
FAs accumulation through blockage of the redox mediated activation of NF-?B
Rensing-Ehl et al., J Inflamm 1995
:
In this cell line
Fas mobilizes the p50/p65 heterodimeric form of NF-kappa B and
induces interleukin-6 (IL-6) production
Yamada et al., Diabetologia 1996
(Autoimmune Diseases...) :
Mouse islet cell lysis mediated by
interleukin-1 induced
Fas
Ben Amor et al., Exp Hematol 1998
:
Together, our data support the notion that the decrease in IL-3 induced histamine and
IL-6 production by splenocytes pretreated with anti-CD3 is
mediated , at least in part, by
Fas/FasL interactions, suggesting that the activity of extramedullary myeloid precursor cells can be modulated by molecules involved in apoptosis
Ayroldi et al., Blood 1998
:
We found that
IL-6 reduced the level of TCR/CD3 induced apoptosis and the expression of
Fas/FasL , yet failed to inhibit IL-2 production
Choi et al., J Immunol 1999
:
Our data demonstrated that : 1 ) FasL is expressed constitutively on astrocytes taken from a fetus or an adult and that its expression increases when these cells are treated with IL-1, IL-6, or TNF-alpha in which the pretreatment of IFN-gamma triggers astrocytes to express more FasL ; 2 ) astrocytes induce apoptosis in MOLT-4 cells through FasL ; 3 )
Fas is also expressed constitutively and is
up-regulated by IL-1,
IL-6 , or TNF-alpha in which the pretreatment of IFN-gamma triggers astrocytes to express more Fas ; 4 ) apoptosis occurs when fetal astrocytes are treated with agonistic anti-Fas IgM Ab after culture with IFN-gamma and TNF-alpha ; and 5 ) TNF related apoptosis inducing ligand is up-regulated in fetal astrocytes with stimuli of IL-1 or TNF-alpha