◀ Back to TNF

CLEC7A — TNF

Text-mined interactions from Literome

Brown et al., J Exp Med 2003 : Here we show that Dectin-1 mediates the production of TNF-alpha in response to zymosan and live fungal pathogens, an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dectin-1 as well as Toll-like receptor (TLR)-2 and Myd88
Yadav et al., Blood 2006 : A similar requirement for dectin-1 in TNF-alpha production was observed for macrophages infected with M bovis Bacillus Calmette-Guerin ( BCG ), M phlei, M avium 2151-rough, and M tuberculosis H37Ra ... The limited production of TNF-alpha by virulent M avium 724 and M tuberculosis H37Rv was not dependent on dectin-1
Harada et al., Microbiol Immunol 2006 (Leukopenia) : Blocking dectin-1 significantly inhibited the induction of TNF-alpha and IL-12p70 production by SCG
Rappleye et al., Proc Natl Acad Sci U S A 2007 : Production of proinflammatory TNFalpha by phagocytes was suppressed either by the presence of the alpha- ( 1,3 ) -glucan layer on yeast cells or by RNA interference based depletion of the host beta-glucan receptor dectin-1
Mezger et al., J Infect Dis 2008 (Aspergillosis) : Silencing of dectin-1 resulted in reduced expression of proinflammatory cytokines ( tumor necrosis factor-alpha and interleukin-12 ), which was also reduced by anti-Dectin-1 antibody treatment prior to exposure to A. fumigatus, zymosan, or Candida albicans
Harada et al., J Interferon Cytokine Res 2008 : Blocking dectin-1 significantly inhibited the induction of TNF-alpha production by SCG
Goodridge et al., J Immunol 2009 : However, priming of bone marrow derived macrophages with GM-CSF or IFN-gamma permits Dectin-1-CARD9 mediated TNF-alpha induction
Huang et al., Infect Immun 2009 : The upregulation of TNF-alpha and downregulation of IL-12p70 required Dectin-1 , but not IL-10
Chaung et al., Vet Immunol Immunopathol 2009 : Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell, whereas p-beta-glucan increased dectin-1/TLR4 and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs
Parti et al., Am J Respir Cell Mol Biol 2010 (Candidiasis...) : However, dectin-1 contributed to the C. albicans stimulated increase in TNF-alpha production that occurred in GM-CSF primed macrophages
Bonfim et al., Med Mycol 2009 : There was a tendency towards an increased TLR2 and dectin-1 mRNA expression in response to fungal cells, mainly to Pb265. P. brasiliensis yeast cells induced the production of pro-inflammatory and anti-inflammatory cytokines, but the low ratio between TNF-alpha and IL-10 in response to zymosan and Pb265 indicates a balanced production of IL-10 and TNF-alpha , while Pb18 predominantly induced TNF-alpha secretion
Salazar-Aldrete et al., J Clin Immunol 2013 (Arthritis, Rheumatoid...) : In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1ß, IL-6 and TNF-a , but not IL-23, upon dectin-1 engagement
Mintz-Cole et al., J Allergy Clin Immunol 2013 (Asthma) : Furthermore, the production of TH17 skewing IL-6, IL-23, and TNF-a by dendritic cells in response to heat killed C cladosporioides was dependent on Dectin-1