◀ Back to TNF
CCR3 — TNF
Text-mined interactions from Literome
Sato et al., J Immunol 2000
:
Stimulation of mature DCs with TGF-beta 1 also enhanced
TNF-alpha induced down-regulation of the expressions of CCR-1,
CCR-3 , CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Cheng et al., J Immunol 2002
:
In this study, we demonstrate that
CCR3 is expressed on a subpopulation of primary human dermal microvascular endothelial cells and is
up-regulated by
TNF-alpha
Croitoru-Lamoury et al., Glia 2003
:
Moreover,
TNFalpha and IL-1beta significantly
increase BOB/GPR15,
CCR2 , and V28/CX3CR1 mRNA levels in both models
Joubert et al., J Immunol 2005
(Asthma) :
Interestingly,
TNF-alpha increases ASMC surface expression of
CCR3 from 33 to 74 %
Lee et al., Br J Pharmacol 2006
:
Rosmarinic acid as a downstream inhibitor of IKK-beta in
TNF-alpha induced upregulation of CCL11 and
CCR3 ... 2. In order to determine the effects of rosmarinic acid on the
TNF-alpha induced
upregulation of CCL11 and
CCR3 in human dermal fibroblasts, we performed an enzyme linked immunosorbent assay for CCL11 and a Western blot assay for CCR3 ... The
TNF-alpha induced expression of CCL11 and
CCR3 genes was attenuated by rosmarinic acid
Ponte et al., Stem Cells 2007
:
TNFalpha increases CCR2,
CCR3 , and CCR4 expression ( as opposed to that of CXCR4 ), together with RANTES membrane binding
Catley et al., IDrugs 2010
(Asthma...) :
This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and
TNFa ,
CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies