Gene interactions and pathways from curated databases and text-mining

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CCR3 — TNF

Text-mined interactions from Literome

Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3 , CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Cheng et al., J Immunol 2002 : In this study, we demonstrate that CCR3 is expressed on a subpopulation of primary human dermal microvascular endothelial cells and is up-regulated by TNF-alpha
Croitoru-Lamoury et al., Glia 2003 : Moreover, TNFalpha and IL-1beta significantly increase BOB/GPR15, CCR2 , and V28/CX3CR1 mRNA levels in both models
Joubert et al., J Immunol 2005 (Asthma) : Interestingly, TNF-alpha increases ASMC surface expression of CCR3 from 33 to 74 %
Lee et al., Br J Pharmacol 2006 : Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha induced upregulation of CCL11 and CCR3 ... 2. In order to determine the effects of rosmarinic acid on the TNF-alpha induced upregulation of CCL11 and CCR3 in human dermal fibroblasts, we performed an enzyme linked immunosorbent assay for CCL11 and a Western blot assay for CCR3 ... The TNF-alpha induced expression of CCL11 and CCR3 genes was attenuated by rosmarinic acid
Ponte et al., Stem Cells 2007 : TNFalpha increases CCR2, CCR3 , and CCR4 expression ( as opposed to that of CXCR4 ), together with RANTES membrane binding
Catley et al., IDrugs 2010 (Asthma...) : This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa , CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies