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APEX1 — FOS
Text-mined interactions from Literome
Fritz et al., Oncogene 1999
:
Phosphorylation of the DNA repair protein
APE/REF-1 by CKII
affects redox regulation of
AP-1 ... Inhibition of CKII mediated phosphorylation of
APE/Ref-1 blocked mutagen stimulated increase in
AP-1 binding
Diamond et al., J Biol Chem 1999
:
Redox factor-1 (Ref-1) mediates the activation of
AP-1 in HeLa and NIH 3T3 cells in response to heat shock ... Electrophoretic mobility shift assay extracts immunodepleted of Ref-1 protein demonstrated that the increase in
AP-1 DNA binding activity following heating was
dependent upon the presence of
Ref-1 and that Ref-1 regulates inducible, but not basal, AP-1 DNA binding activity ... The ability of
Ref-1 from heated cells to
stimulate AP-1 DNA binding was abolished by chemical oxidation and restored by chemical reduction
Monick et al., J Biol Chem 1999
:
There was, however, a significant difference in the amounts of the nuclear protein,
REF-1 ( which
regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins ), in alveolar macrophages compared with monocytes
Yan et al., Biochem Biophys Res Commun 2000
:
Gel shift assays of nuclear extracts immunodepleted of Ref-1 protein demonstrated that IL-2 induced
AP-1 DNA binding is
dependent on the presence of
Ref-1 ... Additionally, reporter gene assays showed that
AP-1 transcriptional activity was
enhanced by the overexpression of
Ref-1 and attenuated by the introduction of antisense Ref-1
Wei et al., Cancer Res 2000
:
In addition, immunodepletion of Ref-1 from nuclear extracts demonstrated that the increase in
AP-1 DNA binding activity after IR was also
dependent upon the presence of
Ref-1 from irradiated cells ... Finally, the ability of both TRX and
Ref-1 from irradiated cells to
stimulate AP-1 DNA binding in nonirradiated nuclear extracts was abolished by chemical oxidation and restored by chemical reduction
Robertson et al., Cancer Res 2001
(Carcinoma, Embryonal...) :
Moreover,
Ape1/ref-1 stimulates the DNA binding activity of transcription factors (
Fos-Jun , nuclear factor-kappaB, Myb, ATF/cyclic AMP-responsive element binding protein family, HIF-1alpha, HLF, PAX, and p53 ) through a redox mechanism and thus represents a novel component of signal transduction processes that regulate eukaryotic gene expression
Guo et al., Am J Transplant 2004
(Liver Diseases...) :
Interestingly,
Ref-1 significantly
increased DNA binding of Stat3, but not
AP-1
O'Hara et al., J Immunol 2006
(Helicobacter Infections) :
Small interfering RNA mediated silencing of
APE-1/Ref-1 inhibited basal and H. pylori
induced AP-1 and NF-kappaB DNA binding activity without affecting the nuclear translocation of these transcription factors and also reduced H. pylori induced IL-8 mRNA and protein
DeMorrow et al., Am J Physiol Gastrointest Liver Physiol 2008
(Hyperplasia) :
Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin
1/redox factor 1 and
AP-1 activation
O'Hara et al., Cytokine 2009
:
Silencing of
Ref-1 in AGS cells
inhibited basal and TNF-alpha induced
AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Wang et al., Biochim Biophys Acta 1994
:
The effect of dithiothreitol is opposite to that observed for the
Ref-1 mediated binding of
Fos/Jun to the ARE or to the related 12-O-tetradecanoyl phorbol-13-acetate responsive element ( TRE )
Hirota et al., Proc Natl Acad Sci U S A 1997
:
AP-1 transcriptional activity is
regulated by a direct association between thioredoxin and
Ref-1 ... We here report the molecular cascade of redox regulation of
AP-1 mediated by TRX and
Ref-1
Asai et al., Biochem Biophys Res Commun 1997
:
These results suggested that increased
Ref-1 by TSH might
regulate the binding activity of
AP-1 in thyroid cells