◀ Back to NOS2

IL17A — NOS2

Text-mined interactions from Literome

Martel-Pelletier et al., Arthritis Rheum 1999 (Osteoarthritis) : Further, we explored the major intracellular signaling pathways through which IL-17 induced iNOS expression and NO production
Miljkovic et al., Cell Mol Life Sci 2003 : The effect of interleukin (IL)-17 on the activation of inducible nitric oxide (NO) synthase ( iNOS ) and subsequent production of NO was investigated ... The expression of iNOS transcription factor IRF-1 was also induced by IL-17 and blocked by all three inhibitors, suggesting that the induction of iNOS by IL-17 might be partly exerted through IRF-1 activation
Miljkovic et al., Cytokine Growth Factor Rev 2004 (Inflammation...) : Here we discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription
Miljkovic et al., Cell Mol Life Sci 2005 (Diabetes Mellitus, Experimental) : IL-17 markedly augmented iNOS mRNA/protein expression and subsequent NO production induced in MIN6 cells or pancreatic islets by different combinations of interferon-gamma, tumor necrosis factor-alpha, and IL-1beta ... The induction of iNOS by IL-17 was preceded by phosphorylation of p38 mitogen activated protein kinase ( MAPK ), and inhibition of p38 MAPK activation completely abolished IL-17 stimulated NO release
Nath et al., J Immunol 2009 (Chronic Disease...) : It also attenuated IFN-gamma and IL-17 induced iNOS and cyclooxygenase 2 expression in RAW267.4 cells, further supporting its anti-inflammatory property
Yang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : [ Effect of curcumin on IL-17 induced nitric oxide production and expression of iNOS in human keratinocytes ] ... IL-17 increased NO levels, and expression of iNOS in HaCaT cells ( P < 0.01 ) ... Curcumin decreased IL-17 induced NO production and the iNOS expression at mRNA ( P < 0.01 ) and protein ( P < 0.01 ) levels significantly ... Curcumin down-regulates IL-17 induced NO secretions and iNOS expression in HaCaT cells, thus provides a theoretical basis for the treatment of inflammatory diseases of skin related to keratinocytes
Liu et al., J Immunol 2012 (Vascular Diseases) : Induction of endothelial nitric oxide synthase expression by IL-17 in human vascular endothelial cells : implications for vascular remodeling in transplant vasculopathy
Obermajer et al., J Exp Med 2013 : Inhibition of NOS2 or cGMP-cGK signaling abolishes the de novo induction of Th17 cells and selectively suppresses IL-17 production by established Th17 cells isolated from OvCa patients