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ADCYAP1 — FOS
Text-mined interactions from Literome
Nagashima et al., Mol Cell Endocrinol 2003
(Pituitary Neoplasms) :
Accordingly,
PACAP stimulated
AP-1 and CREB transcriptional activity and E ( 2 ) inhibited TRE-LUC but not CRE-LUC activation
Falktoft et al., Neuropeptides 2009
(Neuroblastoma) :
Calmodulin interacts with PAC1 and VPAC2 receptors and regulates
PACAP induced
FOS expression in human neuroblastoma cells ... The immediate early response gene FOS is a well-known marker of neuronal activation, so we used a human neuroblastoma cell line NB-1 to explore the role of calmodulin in
PACAP induced
FOS gene expression ... We observed both short-term and prolonged altered
PACAP mediated activation of the
FOS gene in the presence of the calmodulin-antagonist W-7
Falktoft et al., Neuropeptides 2009
(Neuroblastoma) :
PACAP also enhanced the FOS gene expression and individual presence of H-89, BIS, Gö6976 and U0126 partially attenuated the
PACAP induced
FOS mRNA expression ... The resemblance of the signaling pathways involving concomitant activities of PKC, ERK1/2 and PKA in
PACAP regulation of the
FOS and VIP gene expressions suggest for the first time a role of FOS in PACAP induced VIP gene expression in human NB-1 neuroblastoma cells
Yi et al., Diabetes 2010
:
In the hypothalamus,
Fos immunoreactivity
induced by
PACAP-38 was colocalized within autonomic neurons in paraventricular nuclei projecting to preganglionic sympathetic neurons in the spinal cord
Schäfer et al., Eur J Biochem 1996
:
Both
PACAP ( 1-27 ) -peptide and PACAP- ( 1-38 ) -peptide strongly increased the DNA binding activity of the c-fos/ c-jun heterodimer transcription factor AP-1 at 10 nM and also
stimulated AP-1 transcriptional activity up to 20-fold in AR4-2J cells