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CTNNB1 — MMP7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Brabletz et al., Am J Pathol 1999
(Colorectal Neoplasms) :
beta-catenin regulates the expression of the
matrix metalloproteinase-7 in human colorectal cancer
Saeki et al., Dig Dis Sci 2002
(Carcinoma, Squamous Cell...) :
Nuclear
beta-catenin enhances the activating expression of
MMP-7 genes by binding with the T-cell factor/lymphoid enhancer factor family of transcription factors
Mei et al., Carcinogenesis 2002
:
These
MMP inhibitors also
blocked the cytosolic accumulation of
beta-catenin and nuclear formation of beta-catenin/LEF-1 complex
Kong et al., Cancer Res 2004
(Fibroma...) :
Because
beta-catenin can
regulate MMP expression, we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice
Tamamura et al., J Biol Chem 2005
:
Delta-beta-catenin expression markedly
increased expression of MMP-2,
MMP-3 , MMP-7, MMP-9, MT3-MMP, and ADAMTS5
Shibata et al., Int J Oncol 2009
(Carcinoma, Squamous Cell...) :
TGFbeta1 dependent,
MMP7 mediated up-regulation of
beta-catenin/LEF1 signaling and TGFbeta1 activated HMGA2 pathways consequently converged with Slug overexpression, due to disassembly and further repression of E-cadherin expression, which was reproducible in the epithelial mesenchymal transition process without any manipulation
Garg et al., Cancer Res 2010
(Colitis...) :
Despite being a mediator of proinflammatory responses in colitis,
MMP-9 plays a protective role and acts as a tumor suppressor in CAC by modulating Notch-1 activation, thereby
resulting in activation of p21 ( WAF1/Cip1 ) and suppression of
beta-catenin
Pan et al., Histochem Cell Biol 2010
(Neoplasm Invasiveness...) :
Here, we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of
Wnt/beta-catenin signaling and transcriptional
activation of matrix metalloproteinase
MMP-7
Arozarena et al., Oncogene 2011
(Colonic Neoplasms...) :
Downstream of beta-catenin MITF not only suppresses the Rho-GTPase regulated cell morphology of invading melanoma cells, but also interferes with
beta-catenin induced expression of the essential collagenase
MT1-MMP , thus affecting all aspects of an invasive phenotype
Han et al., Med Sci Monit 2012
(Colonic Neoplasms...) :
siRNA mediated down-regulation of
beta-catenin elevated the E-cadherin expression but
reduced the
MMP-7 and CD44v6 expressions, which increased the adhesion between LoVo cells but decreased the adhesion of LoVo cells to fibronectin
Yuan et al., Zhongguo Gu Shang 2012
(Osteoarthritis, Knee) :
Western blotting showed that beta-catenin, MMP-7 expression in OA synoviocytes was significantly higher than normal group, Bushen Huoxue decoction could significantly reduce
beta-catenin , MMP-7 expression ; ELISA results showed that MMP-7 expression of OA synovial supernatant was significantly higher than normal synoviocytes supernatant, Bushen Huoxue decoction significantly
regulated the level
MMP-7 down