◀ Back to IL2

IL2 — PRDM1

Text-mined interactions from Literome

Gong et al., J Immunol 2007 : Cytokine dependent Blimp-1 expression in activated T cells inhibits IL-2 production ... Furthermore, ectopic expression of Blimp-1 by activated T cells inhibited IL-2 production but enhanced granzyme B and CD25 expression
Martins et al., J Exp Med 2008 : Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival ... Using these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled
Küçük et al., Proc Natl Acad Sci U S A 2011 (Lymphoma, Non-Hodgkin) : We observed a progressive increase in PRDM1 expression -- in particular, PRDM1a -- in normal NK cells in response to IL-2 and in normal NK cells activated with an engineered NK cell target, K562-Cl9-mb21, suggesting its role in NK cell homeostasis ... We observed a progressive increase in PRDM1 expression -- in particular, PRDM1a -- in normal NK cells in response to IL-2 and in normal NK cells activated with an engineered NK cell target, K562-Cl9-mb21, suggesting its role in NK cell homeostasis