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MAPK1 — MYC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → MAPK1 (directlyIncreases, MYC Activity)
  Evidence: 91332050;1651323;17081983
• OpenBEL Selventa BEL large corpus: MYC → MAPK1 (directlyIncreases, MYC Activity)
  Evidence: In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways.
• KEGG MAPK signaling pathway: MAPK1/MAPK3 → MYC (protein-protein, phosphorylation)
• KEGG Pathways in cancer: MAPK1/MAPK3 → MYC (protein-protein, activation)
• KEGG Colorectal cancer: MAPK1/MAPK3 → MYC (protein-protein, phosphorylation)
• KEGG ErbB signaling pathway: MAPK1/MAPK3 → MYC (protein-protein, activation)
• WikiPathways ErbB Signaling Pathway: MAPK1 → ELK1/MYC (activation)
• WikiPathways Association Between Physico-Chemical Features and Toxicity Associated Pathways: MAPK1 → MYC (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — MAPK1 (direct interaction, pull down) Jin et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MYC — MAPK1 (direct interaction, pull down) Gupta et al., FEBS Lett 1994*
• IRef Biogrid Interaction: MYC — MAPK1 (direct interaction, enzymatic study) Tournier et al., Proc Natl Acad Sci U S A 1997*
• IRef Innatedb Interaction: MYC — MAPK1 (unknown, -) Gupta et al., FEBS Lett 1994*
• IRef Innatedb Interaction: MYC — MAPK1 (unknown, -) Jin et al., J Biol Chem 2004*

Text-mined interactions from Literome

Whitwam et al., Oncogene 2007 (Cell Transformation, Neoplastic...) : Although both NRAS and KRAS activate mitogen activated protein kinase signaling, only NRAS enhances MYC activity in these cells
Duan et al., Dig Dis Sci 2010 (Bile Duct Neoplasms...) : Our results revealed that the specific MAPK-ERK cascade inhibitor, PD98059, significantly attenuated phosphorylation of c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells
Gramling et al., Cell Death Differ 2012 (Cell Transformation, Neoplastic...) : We report the novel findings that Myc alone induced Ras/Mapk pathway signaling, and increased signaling following growth factor stimulation
Imran et al., Eur J Cancer 2012 : These findings exhibit anticarcinogenic potential of TIS21 via downregulation of c-Myc expression during ATRA induced differentiation of HL-60 cells involving activation and deactivation of two major c-Myc regulators, Erk1/2 and Akt, respectively