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ECT2 — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Justilien et al., J Biol Chem 2011
(Carcinoma, Non-Small-Cell Lung...) :
Both wild-type
Ect2 and a phosphomimetic T328D Ect2 mutant bind the PKC?-Par6 complex,
activate Rac1 , and restore transformed growth and invasion when expressed in NSCLC cells made deficient in endogenous Ect2 by RNAi mediated knockdown ... Our data support a model in which PKC? mediated phosphorylation
regulates Ect2 binding to the oncogenic PKC?-Par6 complex thereby activating
Rac1 activity and driving transformed growth and invasion
Weeks et al., Am J Pathol 2012
(Anaplasia...) :
Inhibition of
ECT2 expression by RNA interference
resulted in decreased
RAC1 and CDC42 activity, but no change in RHO activity, suggesting that ECT2 is capable of activating these pro-migratory Rho family members
Cook et al., Genes & cancer 2011
:
Finally, although Ect2 dependent activation of RhoA has been implicated in cytokinesis,
Ect2 can also
activate Rac1 and Cdc42 to cause growth transformation