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ALK — CASP3
Text-mined interactions from Literome
Kim et al., J Biol Chem 2004
(Carcinoma, Hepatocellular...) :
Short interfering RNA mediated inhibition of Smad3 markedly suppressed
ALK7 induced
caspase-3 activation
Xu et al., J Clin Endocrinol Metab 2004
(Ovarian Neoplasms) :
Transient transfection of Nodal and
ALK7-ca significantly decreased X-linked inhibitor of apoptosis protein ( Xiap ) expression,
activated both
caspase-3 and caspase-9, and increased apoptosis as determined by Hoechst nuclear staining and flow cytometry ... These findings demonstrate that Nodal induces apoptosis and inhibits proliferation via ALK7 and Smad2/3 and that the effect of
Nodal-ALK7 on apoptosis may be
mediated in part by the down-regulation of Xiap and activation of
caspase-9 and caspase-3
Xu et al., Mol Cancer Res 2006
(Carcinoma...) :
Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca induced apoptosis as measured by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay but partially blocked
ALK7-ca induced
caspase-3 activation and did not affect the down-regulation of Xiap by ALK7-ca. Dominant negative Smad2, Smad3, and Smad4 blocked ALK7-ca regulated Xiap and Bax expression and caspase-3 activation