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ESR1 — PIK3CA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
None
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, activates)
Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
Evidence: assay
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
→
AKT1 (AKT1)
(modification, activates)
Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
Evidence: assay
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
None
→
E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1)
(modification, collaborate)
Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003
Evidence: mutant phenotype, assay
-
WikiPathways Estrogen signaling pathway:
ESR1
→
PIK3CA
(activation)
-
WikiPathways Estrogen signaling pathway:
ESR1
→
PIK3CA
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sun et al., Cancer Res 2001
(Breast Neoplasms) :
Moreover, we found that
ERalpha binds to the p85alpha regulatory subunit of PI3K in the absence or presence of estradiol in epithelial cells and subsequently
activates PI3K/AKT2 , suggesting ERalpha regulation of PI3K/AKT2 through a nontranscriptional and ligand independent mechanism
Simoncini et al., Arterioscler Thromb Vasc Biol 2003
:
By using cultured human saphenous vain endothelial cells, we found that cell membrane bound
ERalpha colocalizes with PI3K and may be
responsible for
PI3K activation
Pozo-Guisado et al., Int J Cancer 2004
(Breast Neoplasms) :
Stimulation of
PI3K activity by RES was
ERalpha dependent since it could be blocked by the antiestrogen ICI 182,780
Simoncini et al., Steroids 2004
:
For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the
estrogen receptor dependent
activation of MAPK and
PI3K , leading to relevant pathophysiological consequences, in vitro and in vivo
Tissier et al., J Mol Cell Cardiol 2007
(Myocardial Infarction...) :
In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving
activation of the
estrogen receptor , of
PI3K/Akt and mitochondrial preservation
Benitez et al., Br J Cancer 2007
(Breast Neoplasms...) :
Immunoprecipitation and kinase assays showed that RES inhibited AR- and
ERalpha dependent
PI3K activities in LNCaP and PC-3, respectively
Ma et al., Mol Endocrinol 2007
:
BRCA1 underexpression also enhanced estrogen-inducible
ER-alpha activity in a
PI3K/Akt dependent manner
Lee et al., Mol Cells 2008
(Breast Neoplasms) :
In contrast, the
effect of the
PI3K/Akt inhibitor on
ER alpha was blocked in cells that were treated with LY294002 in the presence of the proteasome inhibitors
Hwang et al., Toxicol Appl Pharmacol 2008
:
Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury :
estrogen receptor dependent up-regulation of
PI3K/Akt and HO-1
Hwang et al., Toxicol Appl Pharmacol 2011
:
These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an
estrogen receptor mediated
PI3K/Akt- and CaMKII/AMPK dependent pathway
Shi et al., Biochim Biophys Acta 2013
:
Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via
estrogen receptor mediated
PI3K/GSK3beta signaling