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IL6 — TLR2

Text-mined interactions from Literome

Wang et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Furthermore, a specific TLR2 blocking monoclonal antibody ( 2392 ) attenuated BLP induced, but not LPS induced, tumor necrosis factor-alpha and interleukin-6 production, indicating BLP rather than LPS as a ligand for TLR2 engagement and activation
Matsumura et al., Immunology 2003 : TRAF6-NF-kappaB pathway is essential for interleukin-1 induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Jang et al., J Immunol 2004 (Tuberculosis) : A key new finding of this study is that production of IL-6 and IL-10 from dendritic cells in response to M. tuberculosis is principally dependent on TLR2
Kurt-Jones et al., J Endotoxin Res 2004 : MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and MCP-1 in response to TLR ligands
Goral et al., J Immunol 2005 (Inflammation) : Furthermore, different TLR ligands stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Seki et al., Hepatology 2005 : However, TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways ... However, TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways
Hajishengallis et al., Infect Immun 2005 : Induction of interleukin-1beta (IL-1beta), IL-6 , IL-8, or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was inhibited by anti-TLR2 but not by anti-TLR4 antibody
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6 , nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Zhang et al., EMBO J 2006 : We found that the serine phosphorylation was crucial for TLR induced interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway
Kuwata et al., Immunity 2006 (Colitis...) : IkappaBNS-deficient macrophages and dendritic cells show increased TLR mediated expression of genes such as IL-6 and IL-12p40, which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Pons et al., Respir Res 2006 (Pulmonary Disease, Chronic Obstructive) : Finally, we demonstrated that IL-6 , whose plasma levels are elevated in patients, up-regulated in vitro TLR-2 expression in monocytes from never smokers
Senn et al., J Biol Chem 2006 (Insulin Resistance) : RNA interference mediated inhibition of TLR2 and MyD88 expression in C2C12 muscle cells resulted in a near complete inhibition of palmitate induced insulin resistance and IL-6 production
Boyd et al., Cardiovasc Res 2006 (Myocarditis) : Ligand activation of TLR2, TLR4 and TLR5, but not TLR3, TLR7 or TLR9, resulted in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1 ... Ligand activation of TLR2 , TLR4 and TLR5, but not TLR3, TLR7 or TLR9, resulted in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1
Flacher et al., J Immunol 2006 : TLR2 and TLR3 ligands increase IL-6 and IL-8 production, while dsRNA alone stimulates TNF-alpha release
Bsibsi et al., Glia 2007 : Moreover, the CD14 triggered TLR2 mediated response in astrocytes lead to the production of CXCL8, IL-6 , and IL12p40, whereas typical TLR induced pro-inflammatory cytokines, like TNF-alpha and IL-1beta, were not produced at detectable levels
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Batra et al., Am J Pathol 2007 : In WT preadipocytes the TLR responsiveness increased during maturation to adipocytes ; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher interleukin-6 production
Iimuro et al., J Gastroenterol Hepatol 2007 : In Myd88 ( -/- ) mice after PH, induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of signal transducer and activators of transcription 3 ( STAT3 ) in the liver, and production of TNF-alpha/IL-6 by and activation of NF-kappaB in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration, while TLR2 , 4 and 9, which recognize Gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6 , IL-10, IL-12 and IFN-gamma by B cells
Peiser et al., J Leukoc Biol 2008 (Inflammation) : Application of anti-TLR1, anti-TLR6, and anti-TLR2 indicated an exclusive role of TLR2 in IL-6 induction in human LCs. Collectively, our results show that TLR2 expressed by LCs mediates inflammatory responses to lipopeptides, which implicates a central role in sensing pathogens in human skin
Yu et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007 (Pneumonia...) : Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as TNF-alpha and IL-6 , attenuate NF-kappaB activity, and inhibit TLR2 and TLR4 expression in polymicrobial sepsis
Conner et al., J Exp Med 2008 : This gene emerged as a negative regulator of TLR2 mediated interleukin (IL)-6 production in MOLF/Ei mice, which expressed IRAK1BP1 mRNA in an allele-specific manner when crossed with the C57BL/6J strain
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls ... Stimulation with TLR2 , TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Bailey et al., Am J Physiol Lung Cell Mol Physiol 2008 : To determine whether TLR2 expression was being regulated by IL-6 , the production of IL-6 was blocked using an IL-6 neutralizing antibody
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2 , TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Castillo et al., Nanomedicine (Lond) 2008 : Ag @ tiopronin nanoparticles were not proinflammatory agents, but remarkably they specifically impaired the IL-6 secretion mediated by TLR2, TLR2/6 , TLR3 or TLR9 stimulation in co-treatment experiments
Ospelt et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : Among the expressed TLRs, TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C ) led to the most pronounced increase in IL-6 , MMP-3, and MMP-13
Xie et al., Biochem Biophys Res Commun 2009 (Breast Neoplasms...) : TLR2 activation increased IL-6 , TGF-beta, VEGF and MMP9 secretion, which are associated with TLR2-NF-kappaB signaling
Lichtnekert et al., American journal of physiology. Renal physiology 2009 (Glomerulonephritis...) : Exposure to necrotic cells activated cultured primary mesangial cells to produce Il-6 in a Tlr2/Myd88 dependent manner
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in response to TLR ligands
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Tang et al., Zhongguo Dang Dai Er Ke Za Zhi 2009 (Herpes Simplex...) : The production and release of IL-6 and IL-10 might be mediated by TLR2 and TLR9
Nichols et al., Am J Pathol 2009 (Encephalomyelitis, Autoimmune, Experimental) : Mechanistically, PE DHC enhances EAE in mice lacking natural killer T cells, fails to enhance EAE in Toll-like receptor 2 (TLR2)-deficient mice and, in vitro, induces dendritic cell interleukin-6 secretion in a TLR2 dependent manner
Lanz et al., Stem Cells Dev 2010 (Encephalomyelitis, Autoimmune, Experimental) : This failure to catabolize trp is not due to defective TLR signaling as demonstrated by induction of interleukin 6 (IL-6) by TLR activation
Frazier et al., J Immunol 2009 (Escherichia coli Infections...) : MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
Weaver et al., Eur J Immunol 2010 : Stimulation of C5aR ( -/- ) DC with OVA and TLR2 ligand Pam ( 3 ) CSK ( 4 ) increased TGF-beta production and induced high levels of IL-6 and IL-23 but only minor amounts of IL-12 leading to differentiation of Th cells producing IL-17A and IL-21
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma, tumor necrosis factor-alpha and IL-6 , which are known to promote DC maturation
Amu et al., Scand J Immunol 2010 : We found that CD25 ( + ) B cells secreted higher levels of IL-6 , IL-10 and INFgamma in response to different TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Peña-Cruz et al., J Invest Dermatol 2010 : PD-1 engagement on iLCs reduced IL-6 and macrophage inflammatory protein (MIP)-1alpha cytokine production in response to TLR2 signals but had no effect on LC maturation
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Wang et al., Infect Immun 2010 (Alveolar Bone Loss) : Porphyromonas gingivalis produces unusual sphingolipids that are known to promote inflammatory reactions in gingival fibroblasts and Toll-like receptor 2 (TLR2) dependent secretion of interleukin-6 from dendritic cells
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : TLR2 activation by the HCV core protein leads to a decrease in interleukin 6 (IL-6) production by human APCs after subsequent stimulation with TLR2 ( homotolerance ) ligands and TLR4 ( cross-tolerance ) ligands ... Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Müller et al., Infect Immun 2010 : SitC not only induced a TLR2 dependent release of IL-6 in primary murine keratinocytes (MKs) but also induced intracellular accumulation of TLR2, which was time and concentration dependent
Hunter et al., TheScientificWorldJournal 2010 (Peritonitis) : Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands
Xiang et al., Am J Pathol 2010 (Lymphoma...) : Exosomes released from tumor cells having been shown to induce interleukin-6 release from myeloid derived suppressor cells in a Toll-like receptor 2/Stat3 dependent manner
Farges et al., Immunobiology 2011 : We found that odontoblasts produce the pro-inflammatory cytokines interleukin (IL)-6 and CXCL8, as well as the immunosuppressive cytokine IL-10 in response to TLR2 agonists
Haidl et al., Int Arch Allergy Immunol 2011 (Hypersensitivity) : Increased mast cell IL-6 production in response to combined TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation dependent conditions
Foldi et al., J Immunol 2010 : Jagged1 induction was augmented by IFN-?, was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways, and elevated Jagged1 expression augmented TLR induced IL-6 production
Lin et al., J Cell Physiol 2011 (MAP Kinase Signaling System) : Peptidoglycan induces interleukin-6 expression through the TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia
Chávez-Sánchez et al., Lipids in health and disease 2010 : The activation of CD14, TLR4 , and TLR2 by mmLDL induces IL-1ß, IL-6 , and IL-10 secretion in human monocytes and macrophages ... The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1ß, IL-6 , and IL-10 secretion in human monocytes and macrophages
Lavoie et al., J Infect Dis 2010 (Infant, Premature, Diseases...) : Preterm neonates had globally attenuated TLR stimulated interleukin (IL)-6 , interferon-a, and, to a lesser extent, tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes
Li et al., Cardiovascular diabetology 2010 : Stimulation of TLR2 or TLR4 induced NF-?B activation, and the expression of ICAM-1, IL-6 and IL-8
Agarwal et al., Arthritis Res Ther 2011 (Fibrosis...) : The ability of IFNa2 to regulate TLR induced interleukin (IL)-6 and CC chemokine ligand 2 production was also assessed
Jiang et al., Int Immunopharmacol 2011 (Sepsis...) : Artesunate not only inhibited TNF-a and IL-6 release but also inhibited mRNA and protein expressions of TLR2 and Nod2, two important receptors, in murine peritoneal macrophages stimulated with heat killed WHO-2, further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines
Vaquero et al., Hepatology 2011 : CONCLUSION : TLR-4 signaling contributes to IL-6 activation after PH, but the Tlr4 independent component appears sufficient for ensuring intact signaling downstream of IL-6
Ather et al., J Immunol 2011 (Disease Models, Animal...) : Furthermore, SAA drives production of IL-1a, IL-1ß, IL-6 , IL-23, and PGE ( 2 ), causes dendritic cell ( DC ) maturation, and requires TLR2 , MyD88, and the NLRP3 inflammasome for secretion of IL-1ß by DCs and macrophages
Tang et al., Contrib Nephrol 2011 (Diabetic Nephropathies...) : In human DN biopsies and PTEC, TLR4is upregulated and plays a permissive role in HG-induced IL-6 and CCL-2 overexpression and monocyte transmigration
Séité et al., J Autoimmun 2011 (Autoimmune Diseases) : As a result, IVIg suppresses TLR induced production of the proinflammatory IL-6 , but not that of the anti-inflammatory IL-10
Chung et al., J Viral Hepat 2011 (Hepatitis B...) : We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with TLR ligands results in impaired IL-6 production by peripheral blood monocytes from HCV infected patients
Liu et al., PloS one 2011 (Inflammation) : We found that the expression of TNF-a and IL-6 induced by TLR2 engagement in uPAR-/- neutrophils was less than that in uPAR+/+ ( WT ) neutrophils
Jin et al., Mol Immunol 2011 (MAP Kinase Signaling System) : Interestingly, results showed that while activation of either TLR4 or TLR2/6 ( TLR2dimerized with TLR6 ), but not TLR2/1 ( TLR2dimerized with TLR1 ), significantly increased IL-6 expression by U937 mononuclear cells, coactivation of TLR4 and TLR2/6, but not TLR4 and TLR2/1, led to a further augmentation on IL-6 expression by increasing IL-6 transcriptional activity, but not mRNA stability
Farrar et al., FASEB J 2012 (Disease Models, Animal...) : Activation of TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as IL-6 and TNF-a
Jia et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2011 : Pe-LPS can induce the expression of IL-6 in osteoblast MC3T3-E1 through CD-14 and TLR-4, but not TLR-2
Wilhelmsen et al., Innate Immun 2012 (Sepsis) : We found that TLR2 activation specifically induces the expression of the genes IL-6 , IL-8, CSF2, CSF3, ICAM1 and SELE by human umbilical vein ECs and human lung microvascular ECs
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a, IFN-a, IL-6 , and IL-12 were measured by multicolor flow cytometry
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Siggs et al., Blood 2012 : Neither the missense nor the null allele affected TLR induced secretion of IL-6
DePaolo et al., J Exp Med 2012 (Inflammation...) : Furthermore, induction of T ( H ) 17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/TLR1 induced IL-6 and IL-23 and the presence of TGF-ß in the intestinal environment
Zamora et al., Cytokine 2012 : Even though TLR-activation induced TNFa, IL-10 and IL-6 production, only recombinant TNFa was able to downregulate CD36
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA, but no other TLR2 ligands
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6 , TNF-a, and IL-12 in BMDCs in response to A. baumannii
Miura et al., Hepatology 2013 (Fatty Liver...) : Here we show that both TLR2 and palmitic acid are required for activation of the inflammasome, interleukin (IL)-1a , and IL-1ß, resulting in the progression of NASH
Lee et al., Arterioscler Thromb Vasc Biol 2012 (Atherosclerosis) : TLR 2 induces vascular smooth muscle cell migration through cAMP response element binding protein mediated interleukin-6 production ... TLR2 deficiency or inhibition of TLR2 signaling with anti-TLR2 antibody suppressed TLR2 agonist induced VSMC migration and IL-6 production, which was mediated via p38 mitogen associated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Melkamu et al., Journal of cell communication and signaling 2013 : TLR2 up-regulation by poly I:C was also reduced by IL-6Ra-nAb and inhibitors of Jak2, Stat3 and NF-?B phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-?B inhibition
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Wang et al., PloS one 2012 (Cell Transformation, Neoplastic...) : Over expressing TLR2 in BMDM prevented CDA-2 and PG from inhibiting NF-?B activation, as well as induction of TNFa and IL-6
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2 , TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6) , and Interleukin-8 (IL-8) )
Karrich et al., Blood 2013 : Although IL-21 did not affect TLR induced type I IFNs, IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Urbonaviciute et al., Arthritis Rheum 2013 (Kidney Diseases...) : TLR-2 deficiency prevented the pristane induced systemic release of interleukin-6 (IL-6) and IL-10
Herath et al., PloS one 2013 (MAP Kinase Signaling System) : METHODOLOGYPRINCIPAL FINDINGS : This study systematically investigated the effects of P. gingivalis LPS1435/1449 and LPS1690 on the expression of TLR2 and TLR4 signal transduction and the activation of pro-inflammatory cytokines IL-6 and IL-8 in human gingival fibroblasts ( HGFs )
Giacomini et al., Eur J Immunol 2013 (Multiple Sclerosis, Relapsing-Remitting) : Furthermore, in MS-derived PBMCs, TLR7 mediated production of IL-6 and the ex vivo expression of B-cell activating factor of the TNF family, two crucial cytokines for B-cell differentiation and survival, were induced by IFN-ß
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88