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BAX — SMAD4

Text-mined interactions from Literome

Li et al., J Biol Chem 2005 (Breast Neoplasms...) : Smad4 induced expression of short Bim isoforms ( by alternative splicing ) and Bax and release of cytochrome c in ERalpha positive cells only, and expression of these apoptotic marker genes was reduced when ERalpha small interfering RNA was introduced ... Notably, Smad4 also promoted short Bim isoform and Bax expression and release of cytochrome c only in ERalpha positive MCF-7 tumor xenografts
Xu et al., Mol Cancer Res 2006 (Carcinoma...) : Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca induced apoptosis as measured by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay but partially blocked ALK7-ca induced caspase-3 activation and did not affect the down-regulation of Xiap by ALK7-ca. Dominant negative Smad2, Smad3, and Smad4 blocked ALK7-ca regulated Xiap and Bax expression and caspase-3 activation