Gene interactions and pathways from curated databases and text-mining

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PRKAB1 — TXNIP

Text-mined interactions from Literome

Shaked et al., PloS one 2011 : AMP activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin interacting protein (TXNIP) in pancreatic beta-cells ... The finding that AMPK mediates nutrient regulation of TXNIP may have important implications for the pathophysiology and treatment of diabetes
Chai et al., Cell Signal 2012 : Moreover, we show that the effect of metformin on Txnip gene transcription is due to the inhibition of mitochondrial complex I and increased glycolysis, and is partially mediated by the AMP activated kinase (AMPK)
Wu et al., Mol Cell 2013 : AMPK dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1
Han et al., Biochem J 2013 : AICAR induction of TXNIP depended on MondoA, but was independent of AMPK ( AMP activated protein kinase ) activation and calcium