◀ Back to AR

AR — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AR → Complex of AR-SRC (directlyIncreases, AR/SRC Activity) Marshall et al., J Biol Chem 2003*
  Evidence: Type I co-activators, such as SRC-1, TIF2, and pCAF/p300, are recruited by agonist-bound AR.
• NCI Pathway Database Regulation of Androgen receptor activity: Src (SRC) → AR/T-DHT complex (AR) (modification, collaborate) Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: Src (SRC) → T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: AR/T-DHT complex (AR) → T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: RACK1 (GNB2L1) → T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1) → T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Regulation of Androgen receptor activity: AR (AR) → Src (SRC) (modification, collaborate) Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: AR (AR) → AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: Src (SRC) → AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: RACK1 (GNB2L1) → AR/RACK1/Src complex (AR-GNB2L1-SRC) (modification, collaborate)
  Guo et al., Cancer Cell 2006*, Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → Src (SRC) (modification, collaborate) Migliaccio et al., EMBO J 2000*, Unni et al., Cancer Res 2004, Cheng et al., Endocrinology 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → T-DHT/AR/PELP1 complex (AR-PELP1) (modification, collaborate)
  Migliaccio et al., EMBO J 2000*, Unni et al., Cancer Res 2004, Cheng et al., Endocrinology 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Nongenotropic Androgen signaling: Src (SRC) → T-DHT/AR/PELP1 complex (AR-PELP1) (modification, collaborate)
  Migliaccio et al., EMBO J 2000*, Unni et al., Cancer Res 2004, Cheng et al., Endocrinology 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: T-DHT/AR/TIF2/CARM1 complex (AR-NCOA2-CARM1) → T-DHT/AR/RACK1/Src complex (AR-GNB2L1-SRC) (transcription, activates)
  Shang et al., Mol Cell 2002, Fu et al., Mol Cell Biol 2003, Majumder et al., Prostate 2006, Kraus et al., Cancer Res 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Nongenotropic Androgen signaling: None → T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) (modification, collaborate)
  Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → HRAS/GTP complex (HRAS) (modification, activates) Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → HRAS/GDP complex (HRAS) (modification, activates) Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → None (modification, activates) Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — AR (direct interaction, two hybrid) Powell et al., Endocr Relat Cancer 2004*
• IRef Biogrid Interaction: SRC — AR (physical association, affinity chromatography technology) Unni et al., Cancer Res 2004
• IRef Biogrid Interaction: SRC — AR (physical association, affinity chromatography technology) Migliaccio et al., EMBO J 2000*
• IRef Biogrid Interaction: SRC — AR (direct interaction, two hybrid) Dotzlaw et al., Mol Cell Endocrinol 2003*
• IRef Hprd Interaction: AR — SRC (two hybrid) Powell et al., Endocr Relat Cancer 2004*, Dotzlaw et al., Mol Cell Endocrinol 2003*
• IRef Hprd Interaction: Complex of SRC-AR-PELP1-AR-SRC-PELP1-PELP1-AR-SRC (in vivo) Unni et al., Cancer Res 2004

Text-mined interactions from Literome

Kraus et al., Cancer Res 2006 (Disease Progression...) : Receptor for activated C kinase 1 ( RACK1 ) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
Maudsley et al., Neuroendocrinology 2006 : GnRH induced c-Src activation resulted in the phosphorylation of expressed Hic-5 and promoted its association with the human androgen receptor