UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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CD247 — TYK2

Pathways - manually collected, often from reviews:

NCI Pathway Database IL12-mediated signaling events: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay