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CNTN2 — TP53

Text-mined interactions from Literome

Pise-Masison et al., Mol Cell Biol 2000 : Tax-NF-kappaB induced p53 inactivation is not due to p300 squelching, since overexpression of p300 does not recover p53 activity in the presence of Tax
Mahieux et al., J Virol 2000 (Cell Transformation, Viral...) : We further investigated HTLV-2A Tax and HTLV-2B Tax effects on p53 activity ... In transient-cotransfection assays, Tax-1 and Tax-2B inactivated p53 by 80 %, while Tax2A reduced p53 activity by 20 %
Pise-Masison et al., AIDS Res Hum Retroviruses 2000 : Analysis of Tax mutants in lymphocytes demonstrates that Tax induced p53 inhibition correlates with the ability of Tax to activate NF-kappaB, but not p300 binding or CREB trans-activation ... Consistent with these results, expression of the I-kappaBalpha ( S32,36A ) mutant that blocks NF-kappaB activation blocks Tax mediated p53 inhibition ... Tax does activate IKKbeta in the p65 KO MEFs, indicating that prenuclear events of NF-kappaB activation are not sufficient for Tax mediated p53 inhibition, but rather NF-kappaB transcriptional activation is critical
Van et al., J Virol 2001 : An examination of published findings reveals serious controversy as to the mechanism ( s ) utilized by Tax to inhibit p53 activity and whether the same mechanism is used by Tax in adherent and suspension cells
Jeong et al., Blood 2004 (Cell Transformation, Viral...) : HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity ... In T lymphocytes, Tax mediated p53 inhibition is dependent on Tax activation of the NF-kappaB pathway and is linked to p53 phosphorylation ... In transient transfection assays, we demonstrate that Tax induces the p53-p65 interaction ... Importantly, Tax mediated p53 inhibition correlates with p65 and p53 interaction
Pise-Masison et al., Frontiers in bioscience : a journal and virtual library 2005 (Cell Transformation, Neoplastic) : Setting the stage for transformation : HTLV-1 Tax inhibition of p53 function
Jeong et al., J Biol Chem 2005 : We have demonstrated previously that Tax inhibits p53 activity through the p65/RelA subunit of NF-kappaB ... We now present evidence that suggests that the upstream kinase IKKbeta plays an important role in Tax induced p53 inhibition through phosphorylation of p65/RelA at Ser-536 ... First, mouse embryo fibroblast (MEF) IKKbeta-/-cells did not support Tax mediated p53 inhibition, whereas MEFs lacking IKKalpha allowed Tax inhibition of p53 ... Third, the IKKbeta-specific inhibitor SC-514 decreased the ability of Tax to inhibit p53 ... Fourth, we show that phosphorylation of p65/RelA at Ser-536 is important for Tax inhibition of p53 using MEF p65/RelA-/-cells transfected with p65/RelA WT or mutant plasmids ... Finally, the ability of Tax to inhibit p53 is distinguished from the NF-kappaB transcription activation pathway
Miyazato et al., J Virol 2005 : We found that, in IKKalpha-/-, IKKbeta-/-, and IKKgamma-/- MEFs, p53 activation of a prototypic responsive plasmid ( pG13-luciferase ) was repressed by wild-type Tax ... Our results highlight the complex nature of Tax mediated repression of p53- activity, which requires further investigation
Jeong et al., Oncogene 2005 (Cell Transformation, Viral) : Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax mediated regulation of p53 transcriptional activity
Pise-Masison et al., Arch Immunol Ther Exp (Warsz) 2005 (Leukemia) : This review will focus on the role of Tax in p53 inhibition
Schavinsky-Khrapunsky et al., Int J Cancer 2008 : Both of these Tax effects on p53 proved to be mediated by Tax induced NF-kappaB related mechanisms
Uittenbogaard et al., J Biol Chem 1995 : In this report, we examined whether Tax might repress transcription of the tumor suppressor p53 , as the p53 gene has recently been demonstrated to be regulated by the bHLH protein c-Myc ... We show that Tax represses transcription of the p53 gene and that this repression is dependent upon the bHLH recognition element in the p53 promoter
Akagi et al., FEBS Lett 1997 (Cell Transformation, Viral) : Our results suggest an important role for Tax1 in the aberrant expression and function of p53 observed in many HTLV-I transformed cells
Pise-Masison et al., J Virol 1998 (Cell Transformation, Viral) : Using Ga14-p53 fusion proteins, we demonstrate that Tax inhibition of p53 transactivation function is independent of sequence-specific DNA binding ... We conclude that Tax is involved in the inactivation of p53 function and stabilization of p53 in HTLV-1 infected cells
Mulloy et al., J Virol 1998 (Cell Transformation, Viral) : Consistent with the negative effect of Tax on p53 , no activity on a p53-responsive promoter was observed upon transfection of HTLV-1 infected T-cell lines