◀ Back to MAP3K1
MAP2K4 — MAP3K1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MAP2K4
—
MAP3K1
Karandikar et al., J Biol Chem 2000*
-
IRef Bind_translation Interaction:
MAP2K4
—
MAP3K1
(experimental interaction detection)
Karandikar et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, enzymatic study)
Gallagher et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, pull down)
Xia et al., Genes Dev 1998*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, enzymatic study)
Chen et al., Methods Enzymol 2006*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(physical association, affinity chromatography technology)
Cheng et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, enzymatic study)
Gallagher et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, enzymatic study)
Ryoo et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(physical association, affinity chromatography technology)
Ryoo et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(physical association, affinity chromatography technology)
Tu et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, pull down)
Takekawa et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(physical association, affinity chromatography technology)
Xia et al., Genes Dev 1998*
-
IRef Biogrid Interaction:
MAP2K4
—
MAP3K1
(direct interaction, enzymatic study)
Xia et al., Genes Dev 1998*
-
IRef Hprd Interaction:
Complex of 82 proteins
(in vivo)
Matsuzawa et al., Science 2008
-
IRef Innatedb Interaction:
Complex of MAP2K4-MAP3K1-CHUK
(unknown, -)
Lee et al., Int Immunopharmacol 2008*
-
IRef Innatedb Interaction:
MAP2K4
—
MAP3K1
(unknown, -)
Lee et al., Int Immunopharmacol 2008*
-
IRef Innatedb Interaction:
MAP2K4
—
MAP3K1
(unknown, -)
Witowsky et al., J Biol Chem 2003*
-
IRef Intact Interaction:
MAP2K4
—
MAP3K1
(physical association, anti tag coimmunoprecipitation)
Xia et al., Genes Dev 1998*
-
IRef Intact Interaction:
MAP2K4
—
MAP3K1
(phosphorylation reaction, protein kinase assay)
Xia et al., Genes Dev 1998*
-
IRef Intact Interaction:
MAP2K4
—
MAP3K1
(physical association, pull down)
Xia et al., Genes Dev 1998*
-
IRef Ophid Interaction:
MAP2K4
—
MAP3K1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Tu et al., Cell Signal 2003
:
They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase (
MAP3K )
activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a
MAP3K phosphorylates and
activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Guan et al., J Biol Chem 1998
:
Furthermore, activation of
MEKK1 increases
SEK1/MKK4 but not MKK3 or MKK6 activity