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IGF1 — SOCS3

Text-mined interactions from Literome

Yadav et al., J Biol Chem 2005 : Northern blot, semi-quantitative reverse transcription-PCR, and real time PCR experiments demonstrated that the JAK/STAT pathway also up-regulated SOCS-3 mainly in response to IGF-1
Gupta et al., Exp Mol Pathol 2011 (Disease Models, Animal...) : Western blot data revealed significantly high SOCS-3 expression in PCASMCs in the presence of either TNF-a or IGF-1 ( 5-6 fold ) alone ... However, in the presence of both TNF-a and IGF-1 the SOCS-3 expression was significantly decreased ( 4-5 fold )
Sinha et al., Cell Signal 2011 (Glioblastoma...) : Importantly, TLR9 agonist reversed the effect of IGF-1 on CXCR4 and SOCS3 expression ... While knockdown of HIF-1a abrogated IGF-1 mediated increase in SOCS3 it elevated IGF-1 induced decrease in CXCR4 levels
Al-Shanti et al., J Cell Biochem 2012 : Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3
van de Loo et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Overexpression of SOCS-3 in bovine chondrocytes reduced IL-1- and LPS induced nitric oxide production and insulin-like growth factor 1-induced proteoglycan synthesis
Dhar et al., Am J Physiol Heart Circ Physiol 2013 : Knockdown of STAT3 by small interfering RNA abolished SOCS3 expression in response to IGF-1 ... Downregulation of SOCS3 in the presence of both TNF-a and IGF-1 in hCASMCs is due to SOCS3 promoter hypermethylation involving STAT3-NFkBp65 interaction