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IGF1 — RB1

Text-mined interactions from Literome

Hirschfeld et al., In Vivo 1994 (Bone Neoplasms...) : Insulin-like growth factor-I may regulate osteosarcoma and the Ewing 's family of tumors ( primitive neuroectodermal tumors )
Dufourny et al., J Biol Chem 1997 (Breast Neoplasms) : In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells