Gene interactions and pathways from curated databases and text-mining

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EPHB2 — NRG3

Text-mined interactions from Literome

Esparís-Ogando et al., Mol Cell Biol 2002 (Breast Neoplasms...) : In MCF7 cells, NRG activated Erk5 in a time- and dose dependent fashion
Goldsmit et al., Cell Mol Neurobiol 2001 : N-acetylcysteine, a ROS scavenger, inhibited NRG induced activation of Ras and Erk and PC12-ErbB-4 cell differentiation
Yang et al., Mol Cell Neurosci 2005 : Moreover, neuregulin induced Erk activation and AChR expression were attenuated when ErbB endocytosis was blocked
Di Segni et al., J Mol Neurosci 2006 : NRG induces prolonged activation of PKB/Akt and Erk
Lok et al., Neuroscience 2007 (Sciatic Neuropathy) : We showed that overexpression of Gbeta1 or Gbeta2 in COS7 cells attenuates NRG induced extracellular signal regulated kinase ( ERK ) 1/2 activation, whereas suppression of Gbeta2 expression in C2C12 myotubes enhances NRG mediated ERK1/2 activation and c-fos transcription