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CAPN6 — PXN
Text-mined interactions from Literome
Carragher et al., J Cell Biol 1999
:
Thus, collagen fragments induce distinct integrin signals that lead to initiation of
calpain mediated cleavage of pp125(FAK),
paxillin , and talin and dissolution of the focal adhesion complex
Liu et al., J Pharmacol Exp Ther 2003
(Anoxia) :
The goal of the present study was to determine the
role of
calpain in changes in plasma membrane permeability and cytoskeleton associated
paxillin , vinculin, talin, and alpha-actinin levels during acute renal cell death
Calle et al., J Cell Sci 2006
:
In the present work, we show that inhibition of
calpain in primary mouse dendritic cells
leads to enhanced accumulation of actin filaments, the Wiskott Aldrich Syndrome protein (WASP), beta ( 2 ) integrins, talin,
paxillin and vinculin in podosomes
Cortesio et al., J Biol Chem 2011
(Neoplasm Invasiveness...) :
To determine whether
calpain mediated
paxillin proteolysis regulates focal adhesion dynamics and cell motility, we mapped the preferred calpain proteolytic site in paxillin
St-Pierre et al., PloS one 2013
:
Degradation of
paxillin in CD45-deficient macrophages is
calpain mediated , as treatment with a calpain inhibitor restores paxillin levels in these cells and enhances cell spreading
Yamaguchi et al., FEBS Lett 1994
:
Unphosphorylated and tyrosine phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro : implications for the possible
involvement of
calpain II in mitosis-specific degradation of
paxillin ... We show here the possible
involvement of
calpain II, known to be localized in focal adhesion plaques, in the degradation of
paxillin