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AR — HDAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of Androgen receptor activity: T-DHT/AR/TIP60 complex (AR-KAT5) → HDAC1 (HDAC1) (transcription, activates) Brady et al., J Biol Chem 1999*, Gaughan et al., J Biol Chem 2001, Gaughan et al., J Biol Chem 2002*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of Androgen receptor activity: AR/T-DHT complex (AR) → HDAC1 (HDAC1) (proteasomal ubiquitin-dependent protein catabolic process, collaborate) Gaughan et al., Nucleic Acids Res 2005*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC1 — AR (physical association, affinity chromatography technology) Gaughan et al., Nucleic Acids Res 2005*
• IRef Biogrid Interaction: HDAC1 — AR (physical association, affinity chromatography technology) Gobinet et al., Biochemistry 2005*
• IRef Biogrid Interaction: HDAC1 — AR (direct interaction, two hybrid) Gaughan et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HDAC1 — AR (physical association, affinity chromatography technology) Gaughan et al., J Biol Chem 2002*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Niki et al., Mol Cancer Res 2003*
• IRef Hprd Interaction: AR — HDAC1 (in vivo) Gaughan et al., J Biol Chem 2002*
• IRef Hprd Interaction: AR — HDAC1 (in vitro) Gaughan et al., J Biol Chem 2002*
• IRef Intact Interaction: Complex of EZH2-HDAC2-HDAC1-AR (physical association, anti bait coimmunoprecipitation) Chng et al., EMBO J 2012*
• IRef Ophid Interaction: AR — HDAC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: AR — HDAC1 (aggregation, confirmational text mining) Gaughan et al., J Biol Chem 2002*

Text-mined interactions from Literome

Zhang et al., Nucleic Acids Res 2005 : Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes
Iacopino et al., Int J Oncol 2008 (Prostatic Neoplasms) : The goal of this study was to assess the effects of an HDAC inhibitor, valproic acid ( VA ), on proliferation, androgen-sensitivity, androgen receptor levels and E-cadherin ( E-cad ) expression in human prostate cancer cells
Fialova et al., Oncol Rep 2013 : Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen independent prostate cancer cell lines