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EGFR — MMP2

Text-mined interactions from Literome

Razandi et al., J Biol Chem 2003 (Breast Neoplasms) : Targeting of only the E domain of ERalpha to the plasma membrane resulted in MMP activation and EGFR transactivation
Hao et al., Circ Res 2004 (Hypertension) : Focusing on alpha ( 1b ) -adrenoceptors, we suggest here that MMP dependent activation of the EGFR promotes vasoconstriction as well as growth
Guerrero et al., Exp Cell Res 2004 (Adenocarcinoma...) : On the other hand, we also found that MMP mediated activation of EGFR can occur in an autocrine manner in cells which secrete uPA
Shah et al., Mol Endocrinol 2005 : These observations in adrenal glomerulosa and hepatic cells demonstrate that LPA phosphorylates ERK1/2 through EGF-R transactivation in a MMP dependent or -independent manner in individual target cells
Cáceres et al., Exp Cell Res 2005 (Breast Neoplasms...) : Our results suggest that the MMP dependent EGFR activation observed in V14 RhoA cells represents the starting point of a signaling route that promotes cell motility by activation of ERK1,2 and further enhancement of proteases production
Roztocil et al., Surgery 2005 : EGFR phosphorylation by plasmin was blocked by inhibition of MMP activity and the ligand HB-EGF
Mori et al., J Surg Res 2006 (Colonic Neoplasms) : In these experiments we used an EGFR inhibitor, AG1478 or matrix metalloproteinase ( MMP ) inhibitor , GM6001
Shah et al., J Neurochem 2006 : Phe induced phosphorylation of the EGF-R , and subsequently of Shc and ERK1/2, was attenuated by inhibition of MMP or HB-EGF with the selective inhibitor, CRM197, or by a neutralizing antibody ... In contrast, phosphorylation of the EGF-R , Shc and ERK1/2 by EGF and HB-EGF was independent of PKC and MMP activity
Kodali et al., Cardiovasc Res 2006 (Atherosclerosis...) : Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells
Chen et al., Mol Pharmacol 2006 : Our data suggest that ET-1-ETA mediated ROS generation can transiently inhibit SHP-2 activity to facilitate the MMP dependent and HB-EGF stimulated EGFR transactivation and mitogenic signal transduction in rat cardiac fibroblasts
Yang et al., J Pharmacol Exp Ther 2006 (Stomach Ulcer) : rCRAMP also increased EGFR and ERK1/2 phosphorylation via an MMP dependent mechanism
Park et al., Cancer Res 2006 (Glioblastoma...) : In addition, inhibitors of epidermal growth factor receptor ( EGFR ; AG490 and AG1478 ), Src ( PP2 ), and p38 ( SB203580 ), EGFR neutralizing antibody, and transfection of DN-Src and DN-p38 significantly blocked IR-induced Akt phosphorylation and MMP-2 secretion
Shah et al., J Steroid Biochem Mol Biol 2006 : Consistent with this, inhibition of matrix metalloproteinases ( MMPs ) with GM6001 reduced ERK1/2 activation by ET-1, consistent with partial involvement of the MMP dependent EGF-R activation in this cascade ... These data demonstrate that ET-1 causes ERK/RSK-1/CREB phosphorylation predominantly through activation of G ( i ) and Src, with a minor contribution from MMP dependent EGF-R transactivation
Lyu et al., Molecular vision 2006 : Inhibition of MMP activity leads to decreased EGFR phosphorylation
Yeh et al., Endocr Relat Cancer 2006 (Adenocarcinoma, Follicular...) : Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A
Kajanne et al., J Cell Physiol 2007 : Here we provide genetic and biochemical evidence that EGF-R- and AP-1 mediated signals are required for MMP expression and collagen contraction in fibroblasts
Song et al., Endocrinology 2007 (Breast Neoplasms) : Using MCF-7 breast cancer cells, we for the first time demonstrated that a sequential activation of IGF-IR, MMP, and EGFR existed in E2 and IGF-I actions, which was supported by evidence that the selective inhibitors of IGF-IR and MMP or knockdown of IGF-IR all inhibited E2- or IGF-I induced EGFR phosphorylation
Adiseshaiah et al., J Cell Physiol 2008 (Lung Neoplasms...) : Furthermore, Fra-1 induced EGFR phosphorylation in an MMP dependent manner, and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion
Gong et al., Mol Cancer Ther 2008 (Neoplasm Invasiveness...) : Inhibitor of MMPs significantly blocked p37 induced EGFR but has little effect on extracellular signal regulated kinase phosphorylation, whereas the p37 induced MMP-2 activation was only partially suppressed by inhibitor of MEK1/2 or by inhibitor of EGFR
Roztocil et al., Surgery 2008 : EGFR phosphorylation by insulin was blocked by inhibition of MMP activity and the ligand HB-EGF
Ogunwobi et al., Br J Biomed Sci 2008 (Adenocarcinoma...) : The MMP inhibitors also abolished leptin induced proliferation as well as leptin induced EGFR tyrosine phosphorylation, but did not affect proliferation or EGFR activation induced by TGFalpha
Muscella et al., Biochem Pharmacol 2009 : In conclusion, these findings supported a model in which cisplatin provokes an oxidant induced MMP-2 dependent EGFR transactivation responsible for the induction of cell apoptosis, a process ascribable to the intracellular signalling of PKC-epsilon and MAPK/p38
Xie et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colonic Neoplasms) : ACh induced MMP1, MMP7 , and MMP10 gene transcription was attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and ERK activation
Küper et al., American journal of physiology. Renal physiology 2009 (MAP Kinase Signaling System) : Taken together, these results indicate that osmotic stress induces MMP dependent activation of EGFR , likely via shedding of TGF-alpha, and downstream activation of Ras and the MAP kinases p38 and ERK1/2, which stimulate TonEBP transactivation activity
Bakken et al., J Vasc Surg 2009 : EGFR phosphorylation by ATF was blocked by inhibition of MMP activity and the ligand HB-EGF
Zhang et al., Int J Gynecol Cancer 2009 (Carcinoma...) : Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways
Nagareddy et al., Cardiovasc Res 2010 (Disease Models, Animal...) : We hypothesized that excessive stimulation of GPCRs such as alpha ( 1 ) -adrenergic receptors activates MMP dependent EGFR transactivation and contributes to the development of hypertension by promoting increased synthesis of contractile proteins in vascular smooth muscle ( VSM )
Williams-Pritchard et al., Am J Physiol Heart Circ Physiol 2011 : Thus MMP mediated EGFR activation appears essential to cardiac protection and signaling via A ( 1 ) ARs and preconditioning
Xie et al., Clin Cancer Res 2011 (Disease Models, Animal...) : EGFR activation increased ES cell proliferation, motility, and invasion and induced cyclin D1, matrix metalloproteinase (MMP) 2 , and MMP9 expression
Sanchez-Guerrero et al., PloS one 2012 : This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and MMP/ADAM dependent EGFR phosphorylation
Dong et al., Am J Pathol 2013 (Carcinoma, Non-Small-Cell Lung...) : Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK mediated up-regulation of MMP-2 and MMP-9 ... In summary, our results showed that Derlin-1 is overexpressed in NSCLC and promotes invasion by EGFR-ERK mediated up-regulation of MMP-2 and MMP-9
Park et al., Exp Dermatol 2013 (MAP Kinase Signaling System) : Reactive oxygen species ( ROS ) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression through initiating extracellular signal regulated kinase ( ERK ) -mediated AP-1 signalling ... Molecular mechanism underlying the effects of CA was also examined in the aspect of MMP expression, ERK/AP-1 pathway, ROS generation and EGFR activation
Pedron et al., Biomaterials 2013 : We also found HA-induced expression of MMP-2 is blocked by +EGFR signaling, suggesting a connection between CD44 and EGFR in glioma malignancy