◀ Back to IRF6
IL18 — IRF6
Text-mined interactions from Literome
Schytte Blix et al., J Periodontal Res 1999
(Aggressive Periodontitis...) :
We have studied the
effect of
lipopolysaccharide (LPS) extracted from these periodontopathogenic bacteria on synthesis of the proinflammatory cytokines,
interleukin-1beta(IL-1beta) , tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) in human whole blood
Conti et al., Brain Res Mol Brain Res 1999
:
The endotoxin lipopolysaccharide (LPS) did not affect
IL-18 in astrocytes, but
LPS robustly
increased IL-18 mRNA in microglia
Klein et al., Cytokine 1999
:
Only
LPS led to a strong increase of
IL-18 mRNA expression peaking after 2 h
Iwagaki et al., Infect Immun 2000
:
The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and
LPS induced production of the proinflammatory cytokines,
interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Tsutsui et al., Immunol Rev 2000
(Disease Models, Animal...) :
LPS induces
IL-18 secretion from Kupffer cells in a caspase-1 dependent manner
Companjen et al., Eur Cytokine Netw 2000
:
Finally, our results show that stimulation of the keratinocyte cell line HaCaT with PMA
LPS or IL-1beta, does not significantly
affect intracellular or released ( pro )
IL-18 levels
Manigold et al., Cytokine 2000
:
After unstimulated preincubation for 48 h, however,
IL-18 transcripts were nearly not detectable by RT-PCR, but
inducible by
LPS or SAC ( P < 0.01 ) ...
LPS mediated
IL-18 gene expression and secretion was CD14 dependent and significantly inhibited by co-incubation of PBMC with neutralizing CD14 antibody ( P < 0.01 )
Fantuzzi et al., Eur J Immunol 2001
:
In conclusion,
IRF-1 regulates
IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Carroll et al., Am J Vet Res 2001
:
Serum prolactin (PRL) concentration was decreased in pigs at 18 C, compared with pigs at 34 C. Challenge with
LPS resulted in an increase in serum PRL concentration at 18 C but had no effect on serum PRL at 34 C. Challenge with LPS
resulted in an increase in expression of tumor necrosis factor-alpha,
interleukin-1 beta, and interleukin-6 receptor mRNA in the hypothalamus
Suk et al., Immunol Lett 2001
:
IFNgamma increased lipopolysaccharide (LPS) induced IL-18 production and caspase-1 expression, while PGE ( 2 ) inhibited
LPS induced
IL-18 production
Samardzic et al., Clin Exp Immunol 2001
:
The effect of phosphodiesterase inhibiting anti-inflammatory drug pentoxifylline ( PTX ) on
LPS induced
IL-18 synthesis and IL-18 mediated IFN-gamma-induction were investigated
Panerai et al., Diabetologia 2001
(Diabetes Mellitus, Type 1...) :
Anti-CD3 and/or
lipopolysaccharide (LPS) induced blood levels of interferon (IFN)-gamma,
interleukin (IL)-4, IL-10, IL-12 and tumour necrosis factor (TNF)-alpha were measured by ELISA in 10 week-old female NOD mice treated for 6 consecutive weeks with either MFP14 or PBS
Zähringer et al., J Endotoxin Res 2001
:
In human mononuclear cells ( hMNC ) the new LA ( tetra ) antagonized
LPS induced release of interleukin-1 (IL-1),
interleukin-6 (IL-6), and tumor necrosis factor (TNF) in a dose dependent manner with identical antagonistic potency as compared with compound 406
Nakajima et al., J Neurochem 2002
:
C8-ceramide as well as
LPS enhanced the production/secretion of BDNF but, different from LPS, did not
induce tumor necrosis factor alpha,
interleukin-1beta , or nitric oxide
Swinney et al., J Biol Chem 2002
:
Ro106-9920 blocked
lipopolysaccharide (LPS) dependent expression of TNFalpha,
interleukin-1beta , and interleukin-6 in fresh human peripheral blood mononuclear cells with IC ( 50 ) values below 1 microm
Bonder et al., Cytokine 2002
:
While IL-4 can suppress
LPS induced
interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Armstrong et al., J Vet Pharmacol Ther 2002
:
Production of the cytokines interleukin-1 (IL-1),
interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in
response to
lipopolysaccharide (LPS) , and the effects of addition of carprofen ( racemate and R and S enantiomers ) were determined
Boneberg et al., Inflamm Res 2002
:
G-CSF influences monocyte functions in an anti-inflammatory way : The stimulation of monocytes with G-CSF results in an attenuation of
LPS induced release of IL-1beta, TNF-alpha, IL-12 and
IL-18
Aikawa et al., Inflamm Res 2002
(Leukemia, Monocytic, Acute) :
T-614 inhibited
LPS stimulated production of TNF-alpha,
interleukin (IL)-6, and IL-8 in a concentration dependent manner with decreasing mRNA levels ( IL-6 and IL-8 )
Li et al., Acta Pharmacol Sin 2002
(Arthritis, Experimental) :
To investigate the effects of leflunomide ( LEF ) on modulating interleukin-1 (IL-1),
interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) production
induced by
lipopolysaccharide (LPS) in peritoneal macrophages ( PMphi ) in adjuvant arthritis rats and elucidate the possible mechanisms of antiinflammatory and antirheumatoid effects of LEF
Lapteva et al., Biochem Biophys Res Commun 2002
:
In DCs,
lipopolysaccharide (LPS) induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL)-1alpha, IL-10, IL-12, and
IL-18 was significantly inhibited by captopril
Joshi et al., J Immunol 2002
(Endotoxemia...) :
The 75 micro g
LPS induced 5.9 +/- 0.9 ng/ml serum
IL-18 at 8 h, which decreased to 2.3 +/- 0.4 ng/ml by 24 h, whereas 500 micro g LPS induced 11.1 +/- 1.6 ng/ml serum IL-18 levels at 8 h, which increased until death
Joshi et al., Infect Immun 2002
(Disease Susceptibility...) :
At 75 micro g,
LPS induced a transient
increase in IL-1beta and
IL-18 levels in serum, whereas at 500 micro g it induced a 1.5-fold-higher IL-18 level in serum, which increased till death
Rouabhia et al., Infect Immun 2002
:
Since oral epithelial cells secrete a variety of cytokines and chemokines in response to oral microorganisms and since C. albicans is closely associated with oral epithelial cells as a commensal organism, we wanted to determine whether
interleukin-18 (IL-18) and gamma interferon ( IFN-gamma ) were produced by oral epithelial cells in
response to C. albicans infection and
lipopolysaccharide (LPS) stimulation ... Both C. albicans and
LPS significantly decreased pro-IL-18 ( 24 kDa ) levels and
increased active
IL-18 ( 18 kDa ) levels
Zhu et al., J Leukoc Biol 2002
:
With DC preparations obtained from murine bone marrow cultured in granulocyte macrophage-colony stimulating factor, the Ps ODN blocked the production of
interleukin-12 and nitric oxide
induced by bacterial DNA, an immunostimulatory cytosine phosphate guanosine dinucleotide ( CpG ) ODN and
lipopolysaccharide (LPS)
Shinkai et al., Reproduction 2003
(Obstetric Labor, Premature...) :
LPS induced premature delivery and an increase in prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ),
interleukin 1alpha (IL-1alpha), IL-6 and IL-10 in the amniotic fluid, and an increase in IL-6 in plasma
Hinz et al., Biochem Biophys Res Commun 2003
(Inflammation) :
Stimulation of cells with
LPS resulted in a profound induction of the expression of COX-2,
interleukin (IL)-1, IL-6, tumor necrosis factor (TNF), and granulocyte-macrophage colony stimulating factor ( GM-CSF )
Park et al., J Neurochem 2003
(Inflammation) :
We observed that ( i ) chloroquine augmented
LPS induced expression of pro-inflammatory cytokines such as lymphotoxin (LT)-beta, tumor necrosis factor (TNF)-alpha,
interleukin (IL)-1alpha, IL-1beta and IL-6 in human astroglial cells, while the same treatment suppressed LPS induced expression of cytokines in monocytic and microglial cells ; ( ii ) chloroquine alone induced expression of pro-inflammatory cytokines in a dose- and time dependent manner in astroglial cells ; ( iii ) other lysosomotropic agents such as ammonium chloride and bafilomycin A1 had minimal effects on cytokine expression ; and ( iv ) chloroquine induced the activation of nuclear factor-kappa B in astroglial cells, which is a required component of chloroquine induction of cytokines
Riedel et al., Int J Mol Med 2004
(Carcinoma, Squamous Cell...) :
LPS stimulated dose-dependently
IL-18 secretion from PBMC of patients and controls in vitro ( p < 0.05 ) ... Incubation with ethanol alone did not affect basal IL-18 secretion, but ethanol reduced
LPS stimulated
IL-18 secretion compared to LPS stimulation alone ... The mRNA expression of
IL-18 in unstimulated PBMC and the
response of PBMC to ethanol and
LPS was similar in patients and controls
Giri et al., J Neurosci 2004
(Inflammation) :
A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited
lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha,
interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Shin et al., J Ethnopharmacol 2004
(Fatigue Syndrome, Chronic) :
KBT ( 1 mg/ml ) significantly inhibited
LPS induced tumor necrosis factor-alpha,
interleukin-10 , and transforming growth factor-beta1 production in PBMC of CFS patients
Fiebich et al., Phytomedicine 2004
:
The Salix extract inhibited the
LPS induced release of tumor necrosis factor-alpha,
interleukin-1beta and interleukin-6 with IC50-values of 180.0, 33.0 and 86.0 microg/ml, respectively
Takahashi et al., Clin Immunol 2004
:
Lipopolysaccharide (LPS) is an
inducer of
interleukin (IL)-18 , which in turn plays important roles in immune responses ... In the present study, we found that LPS at relatively high concentrations ( 10-1000 ng/ml ) induced IL-18 production in a concentration dependent manner both in monocytes isolated from PBMC, and that histamine ( 10 ( -7 ) to 10 ( -4 ) M ) inhibited
IL-18 production
induced by
LPS
Shin et al., FEBS Lett 2004
(Inflammation) :
Furthermore, the compound inhibited not only
LPS induced expressions of tumor necrosis factor-alpha,
interleukin (IL)-1beta , IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS induced apoptosis of the RAW 264.7 cells
Arai et al., J Biol Chem 2004
:
Our results indicate that the neurotoxic effects of
LPS on nigral dopaminergic neurons are
mediated by microglial activation,
interleukin-1beta , and caspase-11 expression in mice
Paintlia et al., J Neurosci Res 2004
(Demyelinating Diseases...) :
Intraperitoneal pretreatment of pregnant female rats with NAC ( 50 mg/kg ), 2 hr prior to administration of LPS at embryonic day 18 ( E18 ), attenuated the
LPS induced expression of inflammatory cytokines such as tumor necrosis factor-alpha,
interleukin-1beta , and inducible nitric oxide synthase in fetal rat brains
Newport et al., Tuberculosis (Edinb) 2004
(Genetic Predisposition to Disease...) :
LPS induced tumour necrosis factor,
interleukin-1 beta and interleukin-10 production was not influenced by TLR4 Asp299Gly genotype
Nuntaprasert et al., Comp Immunol Microbiol Infect Dis 2005
(Respiratory Tract Diseases...) :
Furthermore, the rSwIL-4 successfully suppressed the
LPS induced secretion of TNF-alpha, IL-1alpha, IL-6, IL-8, and
IL-18 from swine alveolar macrophages when rSwIL-4 was treated at the same time with LPS
Thirunavukkarasu et al., J Cell Physiol 2005
:
LPS stimulated the synthesis of TNF-alpha,
interleukin (IL)-6, and IL-1beta but not of TGF-beta in qHSCs
Norata et al., J Intern Med 2005
(Carotid Stenosis) :
Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40,
interleukin (IL)-6 , monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression
induced by
lipopolysaccharide (LPS)
Cheng et al., J Hepatol 2005
:
Recombinant HBsAg inhibits
LPS induced COX-2 expression and
IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1 ... We investigated whether rHBsAg affects
induction of COX-2 and
IL-18 by
LPS and, if so, which signal pathways are involved in a human monocytic cell line, THP-1 ...
LPS induced
IL-18 production was also down-regulated by rHBsAg by interfering mainly with the NFkappaB pathway ... PGE2 reversed the inhibition of
LPS induced
IL-18 production by rHBsAg
Mizuno et al., Immunol Lett 2005
:
Beta2-adrenergic receptor stimulation inhibits
LPS induced
IL-18 and IL-12 production in monocytes ... IL-12 production induced by LPS was inhibited by anti-IL-18 Ab, but IL-18 production by LPS was not inhibited by anti-IL-12 Ab, showing that
LPS induced
IL-18 production without IL-12 production
Ikawa et al., J Leukoc Biol 2005
:
LPS induced serum
IL-18 levels in P. acnes primed mice were reduced significantly by anti-Gr-1 injection ( depletion of neutrophils and macrophages ) but not by a macrophage `` suicide '' technique, using liposomes encapsulating clodronate
Francey et al., Vet Immunol Immunopathol 1992
:
LPS triggering
promoted the secretion of
interleukin-1 , as evidenced by measurement of murine thymocyte costimulatory activity, and transforming growth factor-beta
Kim et al., Antioxid Redox Signal 2005
(Inflammation) :
The
LPS induced expression of inducible proinflammatory genes such as inducible NO synthase,
interleukin (IL)-1beta , IL-6, and granulocyte-macrophage colony stimulating factor was significantly abolished ( IRs=99.1 %, 74.6 %, 74.0 %, and 64.4 %, respectively ) by aframodial
Suzuki et al., Biomed Pharmacother 2006
:
Using enzyme linked immunosorbent assays ( ELISAs ) we showed DHMEQ to inhibit
LPS induced secretion of IL-6, IL-12,
interleukin-1beta (IL-1beta), and TNF-alpha
Schneider et al., World J Gastroenterol 2006
(Fibrosis...) :
In vitro,
LPS stimulated significantly and dose-dependently
IL-18 secretion from PBMC ... Incubation with ethanol reduced
LPS stimulated
IL-18 secretion by about 50 % ... The mRNA expression of
IL-18 in PBMC and the
response of PBMC to ethanol and
LPS was similar in CP patients and controls
Wang et al., J Clin Immunol 2007
:
The effects of atRA on
LPS induced mRNA expression of IL-10, IL-12p40, TNF-alpha,
IL-18 , and TGF-beta in the THP-1 monocyte/macrophage cell line and in cord blood mononuclear cells were measured by competitive RT-PCR ... atRA did not change the
LPS induced mRNA expression of
IL-18 and TGF-beta
Gupta et al., Cell Immunol 2006
:
Serum
IL-18 responses to
LPS increase after pretreatment with CpG containing DNA ... In contrast, IFNgamma-deficiency or anti-IFNgamma pretreatment reduced CpG expanded
IL-18 responses to
LPS by 67 and 83 %, respectively ... CpG, compared to pretreatment with other TLR agonists, optimally expanded
LPS induced
IL-18 responses that correlated with higher levels of circulating IFNgamma levels prior to LPS challenge
Nagarajan et al., J Immunol 2007
:
IFN-gamma production by NKT cells is dependent on
LPS induced IL-12 and
IL-18 from APC
Hadley et al., Shock 2007
(Inflammation) :
At the end of CPB, ex vivo production of tumor necrosis factor alpha,
interleukin (IL) 1beta, IL-8, and IL-10 in
response to PepG or
LPS was virtually abolished ( P < 0.05 )
Sakata et al., Immunology 2007
(Disease Models, Animal...) :
We report here the effects of the most potent SMase inhibitor, SMA-7, on the
LPS mediated release of tumour necrosis factor-alpha,
interleukin-1beta and interleukin-6 from THP-1 macrophages and the pathology of dextran sulphate sodium (DSS) induced colitis in mice
Nishioka et al., J Leukoc Biol 2007
:
Treatment with P. acnes alone induced IL-18 more than twofold in each organ, and P. acnes and
LPS induced a marked
increase in
IL-18 levels in the liver and spleen but decreased in the intestines
Shui et al., Rheumatology (Oxford) 2007
(Disease Models, Animal...) :
First, it is not known whether
LPS can
stimulate mesangial cells (MCs) to secrete the pro-inflammatory cytokine,
interleukin (IL)-18 ... In cultured MCs,
LPS greatly
enhanced IL-18 expression, but did not induce apoptosis, while mouse IL-18 did not induce apoptosis or activate apoptotic signal transduction in MCs ... We infer that
LPS induced
IL-18 production by MCs could be a mediator by which LPS accelerates and exacerbates LN
Foster et al., J Dent Res 2007
:
VIP inhibits P. gingivalis
LPS induced
IL-18 and IL-18BPa in monocytes ... Our objective was to investigate the
effect of Pg
LPS on
IL-18 and its natural inhibitor, IL-18 binding protein ( IL-18BPa ), in human monocytes, and the effect of VIP on this system ... We demonstrated that Pg
LPS induced both
IL-18 and IL-18BPa secretion in cultures of the human monocytic cell line THP-1, as measured by specific ELISA
Boos et al., Am J Cardiol 2007
(Atrial Fibrillation...) :
Effects of
LPS on high-sensitivity C-reactive protein,
interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts as indexes of an inflammatory response were also assessed ...
LPS led to overall marked increases in high-sensitivity C-reactive protein,
interleukin-6 , tumor necrosis factor-alpha, and neutrophil counts ( all p < 0.0001 ) and an average temperature increase of 1.1 degrees C
Kipp et al., J Neuroendocrinol 2007
:
Combined treatment with oestrogen and progesterone together diminished
LPS induced
IL-18 expression in the midbrain completely
Kim et al., Arch Pharm Res 2007
(Periodontitis) :
LPS enhanced ROS production, as well as, expression of pro-inflammatory cytokines such as interleukin-1beta,
interleukin-6 , interleukin-8 and tumor necrosis factor-alpha, and the production and activation of MMP2
Santander et al., Biomedica 2007
(Chagas Disease) :
KMP-1 1 protein does not affect the maturation of dendritic cells, but in the
presence of
LPS the K1 peptide leads to a decreased expression of CD86 and CD83 as well as
interleukin-12 production, This phenomenon may be associated with an impaired T cell stimulation
Hughes et al., Circ Res 2008
(Inflammation) :
Pretreatment of macrophages with 500 nmol/L S1P markedly reduced
LPS mediated secretion of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and
interleukin-12
Motoyoshi et al., Neurochem Int 2008
(Gliosis...) :
Both AmB and
LPS also
induced mRNA expressions of interleukin-1beta,
interleukin-6 , and tumor necrosis factor-alpha in microglia
Chochi et al., Clin Cancer Res 2008
(Helicobacter Infections...) :
H. pylori LPS
induced neither
interleukin-12 nor IFN-gamma production by MNC, although E. coli
LPS did induce production of both significantly
Hollenbach et al., Biochem Pharmacol 2008
:
In contrast, both EP and EL were shown to suppress the
Lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha,
interleukin (IL)-1beta, IL-6 and IL-8 from human immunocompetent cells, and modulated the expression of the immune receptors HLA-DR, CD14 and CD91 on human monocytes
Reikeras et al., J Trauma 2009
(Hip Injuries) :
Ex vivo
lipopolysaccharide (LPS) and peptidoglycan ( PepG )
induced tumor necrosis factor-alpha (TNF-alpha) and
interleukin ( IL-10 ) releases were measured in whole blood sampled preoperatively and added serum taken before, at the end of operation and at postoperative day 1 and 6
Khripko et al., Mediators Inflamm 2008
:
Our results showed that PBMC from donors carrying allele 137C have lower levels of both spontaneous and
LPS stimulated
IL-18 production
Abu Elhija et al., Am J Reprod Immunol 2008
:
LPS increases the expression levels of IL-18, ICE and
IL-18 R in mouse testes
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009
:
LPS induced secretion of prostaglandin E2 ( PGE2 ),
interleukin (IL)-6 , and keratinocyte derived chemokines ( KC ) was measured by ELISA
Avni et al., Immunol Lett 2009
(Inflammation) :
In this study we thus investigated the effect of PCERA-1 on
LPS induced release of TNFalpha,
interleukin (IL)-10 and IL-12p40, in vivo, and ex vivo
Zemans et al., Cell Immunol 2009
:
Furthermore,
LPS induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha,
interleukin-6 , and interleukin-1beta expression are dependent on Tec kinase activity
Kankkunen et al., J Immunol 2009
(Inflammation) :
Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced
LPS dependent secretion of IL-1beta and
IL-18
Zhou et al., Lipids 2009
:
In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides ( MC ) on cytotoxicity of human peripheral blood mononuclear cells ( PBMC ) and the inhibitory activities to
lipopolysaccharide (LPS) induced
interleukin (IL)-18 in PBMC were studied
Suo et al., J Ethnopharmacol 2009
:
Moreover, the effects of MT on soluble intercellular adhesion molecule-1 ( sICAM-1 ),
interleukin-6 (IL-6) and interleukin-8 (IL-8) production
induced by
lipopolysaccharide (LPS) in these cells were evaluated
Zhou et al., Z Naturforsch C 2009
:
Echinocystic acid ( 1 ), an echinocystic acid saponin, 2, and four of its ester saponins, 3-6, obtained from the active fraction of Impatiens pritzellii var. hupehensis, an traditional Chinese medicine for rheumatoid arthritis, were investigated for their effects on
lipopolysaccharide (LPS) induced
interleukin (IL)-18 in human peripheral blood mononuclear cells
Novem et al., Clinical and vaccine immunology : CVI 2009
:
In this study, the biological activities of B. pseudomallei LPS were compared to those of Burkholderia thailandensis LPS, and it was found that both murine and human macrophages produced levels of tumor necrosis factor alpha,
interleukin-6 (IL-6), and IL-10 in
response to B. pseudomallei
LPS that were lower than those in response to B. thailandensis LPS in vitro
Harada et al., Am J Respir Crit Care Med 2009
(Asthma) :
Expression levels of
IL-18 in
response to
LPS stimulation in monocytes were significantly greater in subjects homozygous for the susceptibility G allele at rs5744247 C > G
Asghar et al., American journal of physiology. Renal physiology 2009
(Hypertension...) :
We found that
LPS increased the levels of inflammatory cytokines,
interleukin-6 , and tumor necrosis factor-alpha in the rats given either normal- or high-salt intake
Inaba et al., J Nat Med 2010
(Arthritis, Experimental) :
HP-ext dose-dependently suppressed the
lipopolysaccharide (LPS) induced production of inflammatory cytokines
[interleukin-1beta ( IL-1beta ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) ] in mouse macrophage cells ( RAW 264.7 )
Halade et al., J Immunol 2010
(Lupus Erythematosus, Systemic...) :
Further, FO-DHA lowered
LPS mediated increases in serum
IL-18 levels and caspase-1 dependent cleavage of pro-IL-18 to mature IL-18 in kidneys
Choo et al., Rheumatology (Oxford) 2010
(Arthritis, Rheumatoid) :
In addition, MS-275 and SAHA suppressed
lipopolysaccharide (LPS) induced NF-kappaB p65 nuclear accumulation, IL-6,
IL-18 and nitric oxide ( NO ) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels ... At similar concentrations, MS-275 and SAHA suppressed
LPS induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6,
IL-18 and TNF-alpha secretion in THP-1 monocytic cells
Cheng et al., J Ethnopharmacol 2010
:
Treatment with BPs enhanced phagocytic functions of macrophages ( phagocytosis of apoptotic thymocytes, IgG opsonized sheep red blood cells and chicken red blood cells ) and inhibited
LPS induced productions of NO and proinflammatory cytokines ( interleukin-1beta,
interleukin-6 and tumor necrosis factor-alpha )
Yu et al., Phytother Res 2011
(Inflammation) :
PA significantly inhibited the
LPS induced production of nitric oxide ( NO ),
interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a)
Bagnasco et al., J Endocrinol Invest 1990
:
The following variables were evaluated : T cell proliferation following stimulation with phytohemagglutinin ( PHA ), and anti-CD3 or anti-CD2 monoclonal antibodies ; interleukin-2 (IL-2) and gamma-interferon ( gamma-IFN ) production by PHA stimulated T cells in bulk culture and by T cell clones ; PHA induced IL-2 receptor expression ;
LPS induced
interleukin-1 production by accessory cells
Xin et al., Cell Biochem Funct 2011
:
To determine if microglial cells, a subset of glial cells, are involved in asymmetric production,
interleukin-6 (IL-6), interleukin-1ß (IL-1ß) and nitric oxide ( NO )
responses to
LPS by microglial cells in the right and left cerebral cortices were examined
Reale et al., BMC neuroscience 2011
:
In the simultaneous quantification we found significantly higher levels of constitutively and
LPS induced MCP-1, MIP-1a, IL-8 and
IL-18 , and lower RANTES and IFN? levels released by PBMC of SC patients compared with HC ... In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and
LPS induced production of RANTES and
IL-18 was increased, while both basal and LPS induced MCP-1 production was decreased
Tavano et al., J Innate Immun 2011
:
Suboptimal stimulatory doses ( 5-10 µM ) of apidaecin partially inhibited the
lipopolysaccharide (LPS) induced increase in major histocompatibility complex class II ( MHCII ) and CD86 in macrophages, and the release of selected cytokines/chemokines by both macrophages
[ interleukin (IL)-6 and tumor necrosis factor (TNF)-a ] and monocytes [IL-6, TNF-a, basic fibroblast growth factor (FGF) and eotaxin ]
Liu et al., Neurol Res 2011
:
Both the
LPS and amyloid-beta peptide
enhanced interleukin 1, interleukin 6, and tumor necrosis factor-alpha synthesis and these effects were inhibited by 10 ( -9 ) M coumestrol
Choi et al., Biol Pharm Bull 2011
:
Cornuside significantly inhibited the
LPS induced production of nitric oxide, prostaglandin E ( 2 ), tumor necrosis factor-alpha,
interleukin-6 (IL-6), and IL-1beta
Hung et al., Am J Chin Med 2011
(Drug-Induced Liver Injury...) :
Our results showed that ES reduced
LPS induced nitric oxide ( NO ),
interleukin (IL)-1 , IL-6, reactive oxygen species ( ROS ), and prostaglandin ( PGE ( 2 ) ) production in BV-2 cells
Li et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011
:
Compared with the control group, the expression of
IL-18 , IL-6 and MDA were gradually
increased by
LPS with different concentrations ( P < 0.05 ) ; the expression of targets above were little by little increased with stimulated time prolonging
Uto et al., Int Immunopharmacol 2012
:
Among these jolkinolides, 17-hydroxy-jolkinolide B ( HJB ) exhibited the most potent inhibition of
LPS induced production of inflammatory mediators such as prostaglandin E ( 2 ) ( PGE ( 2 ) ), nitric oxide ( NO ), and pro-inflammatory cytokines
[ interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) ]
Yu et al., Inflammation 2012
(Inflammation) :
Pyranocoumarins significantly inhibited
LPS induced production of nitric oxide,
interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a)
Zhu et al., Zhong Xi Yi Jie He Za Zhi 1990
:
When the drug was added from 0.6 mg/ml to 5 mg/ml a significant dose dependent inhibition effect was shown in the following immune reactions of mice ( P less than 0.05-0.01 ) : phagocytic function of peripheral blood leucocytes assayed by chemiluminescence ; mitogenic response of spleen lymphocytes to Con A ; mixed lymphocyte culture and
LPS induced
interleukin-1 release of macrophages
Zhang et al., Phytochemistry 2012
:
E. paradoxa var. paradoxa, rich in polyenes/polyacetylenes, was an especially efficient inhibitor of
LPS induced production of nitric oxide ( NO ), prostaglandin E2 ( PGE2 ),
interleukin-1 beta ( IL-1ß ) and interleukin-6 (IL-6) by 46 %, 32 %, 53 % and 26 %, respectively, when tested at 20 µg/ml in comparison to DMSO control
Seo et al., Immunopharmacol Immunotoxicol 2012
(Inflammation) :
SPEE treatment significantly inhibited the
LPS induced production of NO, prostaglandin E ( 2 ),
interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Zhu et al., PloS one 2012
:
Our results show that artemisinin significantly inhibited
LPS induced production of tumor necrosis factor-alpha ( TNF-a ),
interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide ( NO )
Reyes et al., Eur J Nutr 2013
(Inflammation) :
Calcium induced thromboxane B ( 2 ) and nitric oxide production,
LPS induced prostaglandin E ( 2 ) and nitric oxide production and LPS induced
interleukin 1ß production were measured
Holen et al., Fish Shellfish Immunol 2012
:
LPS cell activation
increased mRNA expression of interleukin 8
; interleukin-1ß ; cyclooxygenase 2 ; leukocyte derived chemotaxin 2 ; carboxyl-esterase 2 and environmental biomarker cytochrome P450 1A
Kauppinen et al., Immunol Lett 2012
(Macular Degeneration) :
Our results indicate that
LPS and HNE significantly
increased the production of IL-6 and
IL-18 , respectively ...
LPS treatment preceding HNE
induced an even greater increase in the production of
IL-18 than HNE alone
Hebeda et al., Arch Toxicol 2012
:
Hydroquinone treatment impaired
LPS induced nitric oxide ( NO ), tumour necrosis factor a (TNF-a),
interleukin (IL)-1ß and IL-6 secretions by neutrophils
Rajan et al., Spine (Phila Pa 1976) 2013
:
LPS stimulation
resulted in significant increases in tumor necrosis factor a (TNF)-a,
interleukin (IL)-1ß, IL-6, and nitric oxide levels and significant inhibition in aggrecan and collagen-2
Sulyok et al., Br J Anaesth 2012
(Colorectal Neoplasms...) :
The following parameters were measured :
lipopolysaccharide (LPS) induced tumour necrosis factor (TNF)-a, procalcitonin ( PCT ),
interleukin (IL)-6/10, heat shock proteins ( HSPs ) 60, 70, and 90, human leucocyte antigen-DR ( HLA-DR ), and LPS binding protein (LBP)
Byun et al., Biochem Biophys Res Commun 2012
(Inflammation) :
In addition, EGCG treated DCs inhibited
lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a,
interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Zhang et al., Bioorg Med Chem 2012
:
The lead compound 1 ( NCI126224 ) was found to suppress
LPS induced production of nuclear factor-kappaB ( NF-?B ), tumor necrosis factor ( TNF-a ),
interleukin-1ß (IL-1ß), and nitric oxide ( NO ) in the nanomolar-low micromolar range
Jung et al., Arterioscler Thromb Vasc Biol 2012
:
Eicosapentaenoic acid alone or with LPS blunted
LPS mediated stimulation of macrophage proinflammatory interleukin-6,
interleukin-12p40 , and toll-like receptor-4 mRNA and increased anti-inflammatory interleukin-10 and mannose receptor mRNA
Hsiang et al., Food Chem 2013
(Inflammation) :
In vivo and ex vivo imaging showed that LPS increased NF-?B luminescence in the abdominal region, which was significantly inhibited by TS or GA. Immunohistochemical and ELISA analyses confirmed that TS and GA inhibited
LPS induced NF-?B,
interleukin-1ß , and tumour necrosis factor-a expression
Cheng et al., J Sci Food Agric 2013
(Inflammation) :
PV inhibited
LPS stimulated nitric oxide ( NO ), prostaglandin ( PG ) E ( 2 ),
interleukin (IL)-1ß and tumour necrosis factor (TNF)-a release and inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 protein expression
Ro et al., Transplantation 2012
:
Both polyriboinosinic polyribocytidylic acid and
lipopolysaccharide (LPS) stimulation
induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1,
interleukin-8 , and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2013
(Reperfusion Injury) :
In the experiment using isolated Kupffer cells, the expression of interleukin-6,
interleukin-1ß , and endothelin-1 in
response to
LPS stimulation was attenuated by BCAA in a dose dependent fashion
Zhu et al., Biol Pharm Bull 2013
(MAP Kinase Signaling System) :
Mollugin attenuated the
LPS induced expression of nitric oxide ( NO ), inducible nitric oxide synthase (iNOS),
interleukin (IL)-1ß and IL-6 but augmented the expression of tumor necrosis factor (TNF)-a
Chen et al., Food Chem Toxicol 2013
(Inflammation) :
Both water and ethanolic extracts of I. suffruticosa significantly decreased
LPS induced nitric oxide ( NO ) as well as the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-a, and
pro-interleukin-1ß
Song et al., Eur J Pharmacol 2013
(Sepsis) :
In RAW264.7 and mouse peritoneal macrophages, bis-N-norgliovictin dose-dependently inhibited
LPS induced production of TNF-a,
interleukin-6 (IL-6), interferon-ß ( IFN-ß ) and monocyte chemoattractant protein ( MCP-1 ), but without suppressing cell viability
Kang et al., Environ Toxicol Pharmacol 2013
(Inflammation) :
It was demonstrated that
LPS can
induce the production of pro-inflammatory cytokines such as interleukin-1ß (IL-1ß),
interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) as well as the expression of inflammatory mediators as cyclooxygenase-2 (COX-2), and inducible nitric oxide synthases (iNOS) from HepG2 cells
Li et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013
:
To observe the expression of progesterone receptor (PR),
interleukin-1ß (IL-1ß), and cyclooxygenase-2 (COX-2)
induced by
lipopolysaccharide (LPS) or Toll-like receptor 4 antagonist ( TLR4 mAb ) in decidual cells in vitro, and then to explore the effect of LPS and its antagonist on PR of decidual cells and the relation between PR and inflammatory cytokines
Hu et al., Int J Mol Med 2013
:
We found that GLGZD inhibited the inflammatory response in microglial cells as it significantly reduced
LPS induced expression of pro-inflammatory nitric oxide, tumour necrosis factor-a,
interleukin (IL)-6 and IL-1ß in BV-2 cells, in a dose dependent manner
Li et al., Mol Med Report 2013
(Acute Lung Injury...) :
The upregulation of matrix metalloproteinase-9,
interleukin (IL)-1ß , IL-6 and inducible nitric oxide synthase was
induced by
LPS in the mouse model of sepsis and the TC-1 cell line, and resveratrol suppressed the overexpression of these proinflammatory molecules in a dose-dependent manner
Olajide et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Our results showed that cryptolepine significantly inhibited
LPS induced production of tumour necrosis factor-alpha ( TNF a ),
interleukin-6 (IL-6), interleukin-1beta ( IL-1 ß ), nitric oxide, and PGE2
Li et al., Eur J Pharmacol 2013
:
Our data demonstrated that THC significantly inhibited
LPS induced TNF-a,
interleukin-6(IL-6) and nitric oxide ( NO ) production
Shin et al., Neurosci Lett 2013
(Inflammation) :
NK-4 inhibited
LPS induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-a, and
interleukin-1ß in RAW264.7 cells in a time- and concentration dependent manner
Wu et al., Immunopharmacol Immunotoxicol 2013
:
Materials and methods : We evaluated the effect of TBMS1 on
LPS induced production of tumor necrosis factor (TNF)-a,
interleukin (IL)-6 and IL-1ß in the culture supernatants of RAW 264.7 cells by enzyme linked immunosorbent assay
Cavaillon et al., Cell Immunol 1987
:
Inhibition by gangliosides of the specific binding of lipopolysaccharide (LPS) to human monocytes prevents
LPS induced
interleukin-1 production
Sultzer et al., Infect Immun 1988
:
DNA synthesis, polyclonal antibody synthesis, and
interleukin-1 activity were
stimulated by Bordetella pertussis
LPS and Salmonella minnesota R595 LPS, although to a lesser extent than with responder cells
Ernst et al., J Clin Immunol 1986
(Acquired Immunodeficiency Syndrome) :
In particular, we found a transient increase in C3b receptor mediated monocyte activation in ARC patients ; no influence of therapy on the otherwise intact
LPS induced
interleukin-1 production in vitro ; in some patients a transient corrective influence on the high pretherapeutic immunoglobulin secretion of B cells and their nonresponsiveness to pokeweed mitogen ; low T-cell responses to soluble antigens and alloantigens, which were partially restored during rIL-2 treatment in ARC patients and in one AIDS patient ; defective NK activity in PBMC of two AIDS patients, which was found to be restored when measured at the end of rIL-2 therapy ; and a rather constant phenotypic pattern of PBMC in each patient during therapy except for the decreasing proportion of OKT9 positive lymphocytes in AIDS patients, the increasing proportion of Leu8-Leu3a+ lymphocytes in all patients, and in particular, the transient significant decrease in the Leu7+/OKT3+ ratio, which pretherapeutically was very high in AIDS patients ( 0.78 +/- 0.21 ) and high in ARC patients ( 0.48 +/- 0.06 ) as compared to healthy controls ( 0.18 +/- 0.08 )
Cavaillon et al., Mol Immunol 1986
:
Polymyxin-B inhibition of
LPS induced
interleukin-1 secretion by human monocytes is dependent upon the LPS origin
Billiar et al., Ann Surg 1988
:
When cultured alone, Kupffer cells from these animals also produced more
interleukin-1 ( p less than 0.002 ) and prostaglandin E2 ( PGE2 ) ( p less than 0.009 ) in
response to
LPS
Fujiwara et al., J Gen Microbiol 1988
:
These
LPS also
enhanced interleukin-1 production by murine peritoneal macrophages and mouse cell line J744
Warren et al., Infect Immun 1988
:
These data suggest that there may exist a self regulated mechanism for decreasing the toxicity of LPS and the production of
LPS induced
interleukin-1 ; this mechanism is controlled by a macrophage factor and functions through altering the binding of LPS to certain serum lipoproteins
Gallily et al., Cancer Immunol Immunother 1986
(Neoplasms, Experimental) :
However,
LPS induced
interleukin 1 release was partially ( 55 % ) suppressed by embryonic fibroblast culture supernatant
Lundgren et al., Eur J Immunol 1995
:
Smu-S gamma 1 switch recombination in
lipopolysaccharide (LPS) + interleukin-4 (IL-4)
activated mouse B cells was assayed by a digestion-circularization polymerase chain reaction
Fahmi et al., Cell Immunol 1993
:
To achieve a better understanding of the mechanism of this type of desensitization, we studied the regulation of the production of
interleukin 1, interleukin 6, and tumor necrosis factor alpha by mouse peritoneal macrophages in
response to
LPS , after a preliminary exposure to LPS or to structurally related synthetic lipids
Daniel et al., Vet Immunol Immunopathol 1993
:
While resting cells produced no detectable interleukin 1, stimulation with
lipopolysaccharide (LPS) induced the production of biologically active
interleukin 1
Sugiyama et al., Infect Immun 1996
:
In contrast,
LPS induced
interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Persoons et al., Am J Respir Cell Mol Biol 1996
:
When alveolar macrophages were cultured, substantial amounts of interleukin-1(IL-1),
interleukin-6 (IL-6), tumor necrosis factor alpha(TNF-alpha), and nitric oxide are produced upon
stimulation with
LPS
Suttles et al., J Leukoc Biol 1996
:
Recent studies have demonstrated that monocytes can be rescued from apoptosis via
lipopolysaccharide (LPS) activation or
stimulation with
interleukin-1 or tumor necrosis factor-alpha
West et al., Ann Surg 1997
:
Macrophages incubated in CO2 produced significantly less TNF and
interleukin-1 in
response to
LPS compared to incubation in air or helium
Sastre et al., Biochem J 1998
:
In the present study we sought to determine : ( a ) whether macrophages ( cell line RAW 264.7 ) express ADC and agmatinase, and ( b ) if the enzymes are
regulated by
lipopolysaccharide (LPS) , and/or by the inhibitory cytokines transforming growth factor-beta ( TGF-beta ),
interleukin-10 (IL-10) and interleukin-4 (IL-4)
Ju et al., Pharmacology 1998
(Disease Models, Animal...) :
In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF),
interleukin-1 (IL-1) and interleukin-6 (IL-6)
induced by
lipopolysaccharide (LPS) in mice
Amura et al., Infect Immun 1998
(Sepsis) :
These cells manifested markedly enhanced levels of in vitro TNF-alpha,
interleukin 6 (IL-6), and nitric oxide production in
response to
LPS