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IFNG — NTRK1

Text-mined interactions from Literome

Shikata et al., Med Pediatr Oncol 2000 (Neuroblastoma) : Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma ... Previously, we found that interferon-gamma (IFN-gamma) can enhance TrkA mRNA expression in NB cell lines ... The effect of IFN-gamma on the TrkA mRNA expression was screened in six human NB cell lines and a freshly prepared sample, SK-rib, from a stage IV patient ... Although the degree of morphological differentiation did not increase in proportion to the TrkA expression induced by IFN-gamma , continuous loading of both IFN-gamma and NGF caused marked morphological differentiation in a cultured KP-N-RT cell line and SK-rib cells during 10 days
Wang et al., Zhonghua Er Ke Za Zhi 2004 (Neuroblastoma) : In contrast with the induction of TrkA mRNA expression by IFN-gamma , the combination treatment could decrease TrkA mRNA expression, which might indicate that a kind of negative feedback mechanism existed
Lucarelli et al., J Biol Chem 1995 (Neuroblastoma) : Selective regulation of TrkA and TrkB receptors by retinoic acid and interferon-gamma in human neuroblastoma cell lines ... Similar to RA, IFN-gamma does not modify the transcriptional rate of TrkA mRNA, but rather increases TrkA mRNA stability ... Thus, RA and IFN-gamma differentially regulate TrkA or TrkB expression in the same cell type by predominantly transcriptional ( TrkB ) or post transcriptional ( TrkA ) mechanisms