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PREX1 — RAC3

Text-mined interactions from Literome

Dinauer et al., Curr Opin Hematol 2003 : Rac activation in response to neutrophil chemoattractants may be regulated in large part by a newly identified guanine nucleotide exchange factor, P-Rex1 , which is activated by either phosphatidylinositols or Gbetagamma subunits
Waters et al., J Cell Sci 2008 : P-Rex1 activated Rac3 GTPase activity when coexpressed in PC12 cells
Qin et al., Oncogene 2009 (Lymphatic Metastasis...) : Silencing endogenous P-Rex1 in metastatic prostate cancer PC-3 cells selectively inhibited Rac activity and reduced cell migration and invasion in response to ligands of both epidermal growth factor receptor and G-protein coupled CXC chemokine receptor 4 ... Thus, by functioning as a coincidence detector of chemotactic signals from both GPCRs and RTKs, P-Rex1 dependent activation of Rac promotes prostate cancer metastasis
Naikawadi et al., Circ Res 2012 : TNF-a stimulated Rac activation and reactive oxygen species production in a P-Rex1 dependent manner