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CCND1 — MAP2K1

Text-mined interactions from Literome

Terada et al., Nephrol Dial Transplant 1999 : In contrast, constitutive active MKK1 , the classical p42/44 MAPK activator, increased cyclin D1 promoter activity and level of protein
Terada et al., Kidney Int 1999 : In contrast, overexpression of the active form of MKK1 , the classic MAPK-activator, MKK1 increased cyclin D1 promoter activity and protein level, as well as the percentages of S and G2/M phases
Rimerman et al., J Biol Chem 2000 : The ability of a dominant negative cyclin D1 mutant, D1-T156A, to inhibit Wnt1/MEK1 dependent S-phase entry suggests that cyclin D1 is a critical downstream target for Wnt1- and MEK1 dependent cellular proliferation
Lotfi et al., Endocr Res 2000 (Adrenal Cortex Neoplasms) : But, the MEK1 inhibitor, PD98059 ( 50microM ), inhibits cFos and cyclin D1 induction and DNA synthesis stimulation by both ACTH39 and FGF2, suggesting that ERK1/2 activation mediates the strong and the weak mitogenic effect of, respectively, FGF2 and ACTH39
Nofer et al., Thromb Haemost 2001 (MAP Kinase Signaling System) : PD98059, an inhibitor of MEK-1 blocked the mitogenic activity of HDL and cyclin D1 expression
Huynh et al., Int J Oncol 2004 (Carcinoma, Hepatocellular...) : Ectopic expression of activated MEK1 in HepG2 cells increased cyclin D1 and Cdk-2 expression, phosphorylation of pRB at Ser780 and Ser795, and percentage of cells in S phase
Ding et al., J Gastroenterol Hepatol 2008 (Helicobacter Infections...) : MEK1/2 inhibition increased p21, p27 and cyclin E and JNK inhibition additionally increased cyclin D1 expression
Lavoie et al., J Biol Chem 1996 : Conversely, activation of this signaling pathway by expression of a constitutively active MKK1 mutant dramatically increased cyclin D1 promoter activity and cyclin D1 protein expression, in a growth factor independent manner
Diehl et al., Genes Dev 1998 : In contrast, Ras mutants defective in PI3K signaling, or constitutively active mitogen activated protein kinase-kinase ( MEK1 ) mutants that act downstream of Ras to activate extracellular signal regulated protein kinases ( ERKs ), can not stabilize cyclin D1
Aziz et al., Mol Cell Biol 1999 : Activation of Raf, v-Src, and MEK1 led to induced expression of c-Myc and cyclin D1