Rodriguez et al., J Exp Med 2005
(Carcinoma...) :
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
Vecchio et al., J Biol Chem 2012
:
Mutational analyses have established that an interaction of the carboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2 , suggesting that hydrophobic interactions between the ?-end of substrates and cyclooxygenase channel residues play a significant role in COX-2 mediated oxygenation