Mao et al., Cancer prevention research (Philadelphia, Pa.) 2008
(Carcinoma...) :
Exogenous LTB4 inhibited LPS induced 5-LOX activity and accentuated the down-regulation of 5-LOX mRNA, whereas suppression of 5-LOX abrogated the LPS induced changes, suggesting a negative feedback mechanism
Lin et al., Vet Immunol Immunopathol 2010
:
The LOX inhibitor nordihydroguaiaretic acid ( NDGA ) prevented LTB4/LTC4 release and BMBMC degranulation
Jiang et al., J Immunol 2011
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13'-Carboxychromanol, a long-chain metabolite of dT, suppressed neutrophil- and HL-60 cell generated LTB ( 4 ) with an IC ( 50 ) of 4-7 µM and potently inhibited human recombinant 5-LOX activity with an IC ( 50 ) of 0.5-1 µM