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CTNNB1 — FGF19

Text-mined interactions from Literome

Treichel et al., Genes Dev 2003 : We present evidence that mBtd is required during early limb development to maintain, but not to initiate Wnt/beta-catenin dependent FGF , Shh, and BMP mediated signaling
Maegawa et al., Development 2006 : By contrast, when FGF signaling is inhibited, beta-catenin did not induce goosecoid and chordin, repress bmp4 expression or induce a dorsal axis ... These results demonstrate that FGF signaling is necessary for beta-catenin induction of the zebrafish organizer
Katoh et al., Cancer Biol Ther 2007 (Helicobacter Infections...) : WNT-beta-catenin-TCF/LEF signaling induces upregulation of MYC, CCND1, WISP1, FGF20 , JAG1 and DKK1 genes
Desnoyers et al., Oncogene 2008 (Carcinoma, Hepatocellular...) : The efficacy of the antibody in these models was linked to inhibition of FGF19 dependent activation of FGFR4, FRS2, ERK and beta-catenin
Ambrosetti et al., Mol Cell Biol 2008 : FGF did not significantly affect the activation of beta-catenin , although it reduced both the expression of TCF/LEF factors and their induction by Wnt. Microarray analysis using osteoblasts treated with Wnt3a and FGF alone or in combination showed that about 70 % of the genes induced by Wnt3a were downregulated by combined FGF treatment
Pai et al., Cancer Res 2008 (Colonic Neoplasms) : FGF19 increases p-GSK3beta and active beta-catenin levels and anti-FGF19 antibody ( 1A6 ) treatment abrogates this effect of FGF19 ... Consistent with the reduced beta-catenin activation, Taqman analyses show that FGF19/FGFR4 inhibition reduced beta-catenin target gene ( cyclin D1, CD44, c-jun, Cox-2, UPAR ) expression