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EGFR — PTPN1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by PTP1B: PTP1B (PTPN1) → EGF/EGFR complex (EGF-EGFR) (modification, activates)
  Xie et al., Biochemistry 2002*, Haj et al., J Biol Chem 2003*, Flint et al., Proc Natl Acad Sci U S A 1997*
  Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — PTPN1 (direct interaction, enzymatic study) Zhang et al., J Biol Chem 1996*
• IRef Biogrid Interaction: EGFR — PTPN1 (association, x-ray crystallography) Sarmiento et al., Biochemistry 2000*
• IRef Hprd Interaction: EGFR — PTPN1 (in vivo) Sarmiento et al., Biochemistry 2000*, Dadke et al., Mol Cell Biochem 2001*, Li et al., Arch Biochem Biophys 2003*, Jia et al., Science 1995*, Zhang et al., J Biol Chem 1996*, Liu et al., Biochem J 1997*
• IRef Hprd Interaction: EGFR — PTPN1 (in vitro) Sarmiento et al., Biochemistry 2000*, Dadke et al., Mol Cell Biochem 2001*, Li et al., Arch Biochem Biophys 2003*, Jia et al., Science 1995*, Zhang et al., J Biol Chem 1996*, Liu et al., Biochem J 1997*
• IRef Intact Interaction: EGFR — PTPN1 (physical association, anti tag coimmunoprecipitation) Flint et al., Proc Natl Acad Sci U S A 1997*
• IRef Intact Interaction: EGFR — PTPN1 (colocalization, fluorescence microscopy) Flint et al., Proc Natl Acad Sci U S A 1997*
• IRef Intact Interaction: EGFR — PTPN1 (phosphorylation reaction, protein kinase assay) Liu et al., Biochem J 1997*
• IRef Intact Interaction: EGFR — PTPN1 (physical association, anti bait coimmunoprecipitation) Liu et al., Biochem J 1997*

Text-mined interactions from Literome

Arias-Romero et al., Cancer Res 2009 (Cell Transformation, Neoplastic) : Activation of ErbB2, but not ErbB1 , increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src dependent transformed phenotype
Eden et al., Nat Cell Biol 2010 : The population of EGFR interacting with PTP1B is the same population that undergo ESCRT mediated ( endosomal sorting complex required for transport ) sorting within MVBs, and PTP1B activity promotes the sequestration of EGFR on to MVB internal vesicles
Ponnusamy et al., American journal of physiology. Renal physiology 2013 (Acute Kidney Injury...) : Collectively, these results indicate that nonlethal necrotic RPTC-Sup can induce inactivation of renal interstitial fibroblasts, which occurs through a mechanism involved in PTP1B mediated inhibition of EGFR signaling