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PIAS3 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → PIAS3 (decreases, PIAS3 Activity)
  Evidence: STAT3 mediated signaling pathways can be inhibited by PIAS3 (protein inhibitor of activated STAT3), which was recently found to regulate protein stability and function by its SUMO (small-ubiquitin like modifiers) ligase activity in promoting sumoylation of important nuclear proteins.
• KEGG Jak-STAT signaling pathway: PIAS1/PIAS2/PIAS3/PIAS4 → STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 (protein-protein, inhibition)
  
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, activates)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer ) complex (STAT3) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, collaborate)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer ) complex (STAT3) → PIAS3/MITF complex (PIAS3-MITF) (modification, collaborate)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: MITF (MITF) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, collaborate)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) → PIAS3/MITF complex (PIAS3-MITF) (modification, collaborate)
  Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: STAT3 — PIAS3 Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Bind_translation Interaction: STAT3 — PIAS3 (unspecified method) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: STAT3 — PIAS3 (physical association, affinity chromatography technology) Okumura et al., J Cell Sci 2010*
• IRef Biogrid Interaction: STAT3 — PIAS3 (physical association, affinity chromatography technology) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: STAT3 — PIAS3 (physical association, affinity chromatography technology) Tsuruma et al., Oncogene 2008*
• IRef Biogrid Interaction: STAT3 — PIAS3 (physical association, affinity chromatography technology) Yamamoto et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: STAT3 — PIAS3 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: STAT3 — PIAS3 (physical association, affinity chromatography technology) Wang et al., J Biol Chem 2001*
• IRef Hprd Interaction: STAT3 — PIAS3 (in vivo) Wang et al., J Biol Chem 2001*, Yamamoto et al., Biochem Biophys Res Commun 2003*
• IRef Intact Interaction: STAT3 — PIAS3 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Mppi Interaction: STAT3 — PIAS3 (coimmunoprecipitation) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Ophid Interaction: STAT3 — PIAS3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: STAT3 — PIAS3 (aggregation, confirmational text mining) Yamamoto et al., Biochem Biophys Res Commun 2003*

Text-mined interactions from Literome

Nojiri et al., Biochem Biophys Res Commun 2004 (Carcinoma, Hepatocellular) : In the luciferase assay, ATBF1 was found to have no influence on STAT3 signaling induced by IL-6 stimulation, but it did synergistically enhance PIAS3 inhibition of activated STAT3
Levy et al., Blood 2006 : This motif ( PIAS82-132 ), which contains 50 amino acids, is sufficient for the inhibition of both MITF and STAT3
Stärkel et al., Lab Invest 2007 (Hepatitis C, Chronic...) : Stat3 DNA binding inversely correlated with Pias3 expression and Stat3-Pias3 interaction increased with the progression of fibrosis
Brantley et al., Clin Cancer Res 2008 (Glioblastoma) : Conversely, PIAS3 overexpression inhibited STAT-3 transcriptional activity, expression of STAT-3 regulated genes, and cell proliferation ... We propose that the loss of PIAS3 in GBM contributes to enhanced STAT-3 transcriptional activity and subsequent cell proliferation
Correa-de-Santana et al., J Endocrinol 2009 : Furthermore, silencing STAT3 inhibited basal, LPS and MDP stimulated NFKB protein expression and overexpression of protein inhibitor of activated STAT3 ( Pias3 ) markedly decreased basal NFKB activity
Dabir et al., Mol Cancer Res 2009 (Carcinoma, Non-Small-Cell Lung...) : STAT3 transcriptional activity can be negatively regulated by protein inhibitor of activated STAT3 ( PIAS3 ) ... STAT3 transcriptional activity can be negatively regulated by protein inhibitor of activated STAT3 ( PIAS3 ) ... These data suggest an important role for the negative regulatory effect of PIAS3 on STAT3 in EGF-driven tumors
Kluge et al., Mol Oncol 2011 (Carcinoma, Non-Small-Cell Lung...) : We have previously demonstrated the concentration dependent negative regulatory effect of PIAS3 on STAT3 signaling and its capacity to decrease lung cancer proliferation and synergize with epidermal growth factor inhibition
Chung et al., Science 1997 : PIAS3 blocked the DNA binding activity of Stat3 and inhibited Stat3 mediated gene activation