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PTPN11 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): Src (SRC) → HGF(dimer)/MET(dimer)/GAB1/SHP2 complex (MET-GAB1-PTPN11-HGF) (modification, activates)
  Chan et al., J Biol Chem 2003*, Chan et al., Oncogene 2010
  Evidence: mutant phenotype, assay
• Reactome Reaction: PTPN11 → SRC (indirect_complex) Schneider et al., Biochem Biophys Res Commun 2000*, Tauchi et al., J Biol Chem 1994, Miyatake et al., Biochem Biophys Res Commun 1998
• Reactome Reaction: PTPN11 → SRC (reaction) Schneider et al., Biochem Biophys Res Commun 2000*, Montagner et al., J Biol Chem 2005, Tauchi et al., J Biol Chem 1994, Miyatake et al., Biochem Biophys Res Commun 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: SRC — PTPN11 (in vivo) Doan et al., Cell Signal 2004*
• IRef Intact Interaction: Complex of SRC-CSK-PTPN11-PXN (association, anti bait coimmunoprecipitation) Ren et al., J Biol Chem 2004
• IRef Intact Interaction: SRC — PTPN11 (dephosphorylation reaction, phosphatase assay) Edouard et al., Mol Cell Biol 2010*

Text-mined interactions from Literome

Walter et al., Oncogene 1999 (Cell Transformation, Neoplastic) : To determine whether Shp-2 regulates Src kinase activity, we measured Src activity in cells overexpressing wild-type or catalytically-inactive C463S Shp-2
Cunnick et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Mek1 activation by Gab1PH-SHP2DeltaN was inhibited by an Src inhibitor and by Csk ... Significantly, Gab1PH-SHP2DeltaN induced Src activation
Ren et al., J Biol Chem 2004 : Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor ... Expression of an SHP2 binding defective mutant of Gab1 ( Gab1FF ) or a catalytically inactive mutant of SHP2 ( SHP2DN ) prevented paxillin tyrosine dephosphorylation and Src activation induced by EGF
Zhang et al., Mol Cell 2004 : Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
Goto et al., Int J Cancer 2006 (Atrophy...) : The CagA protein is injected from attached H. pylori into gastric epithelial cells and undergoes Src dependent tyrosine phosphorylation and activation of the eukaryotic phosphatase SHP-2
Li et al., Biochem Biophys Res Commun 2006 : This activation was inhibited by PP2 not by AG1478, which suggests Src dependent activation of SHP-2
Merdek et al., J Biol Chem 2007 : Dimerization of the beta4 intracellular domain results in the binding and activation of the tyrosine phosphatase SHP-2 and the activation of Src , events that also occur upon ligation of intact alpha6beta4
Kusano et al., Endothelium : journal of endothelial cell research 2008 : To see if tyrosine kinases other than Src are also capable of phosphorylating PZR, the authors cotransfected HEK293 cells with PZR and one of several tyrosine kinases and found that c-Src , c-Fyn, c-Lyn, Csk, and c-Abl, but not c-Fes, phosphorylated PZR and increased PZR/SHP-2 interaction
Carver et al., J Biol Chem 2010 (Breast Neoplasms) : Src family kinase activity was required for IGF-IR association with SHP-2 , ligand induced IGF-IR internalization, and PRL enhanced IGF-IR phosphorylation
Lennartsson et al., Cell Signal 2010 : We could also demonstrate that Shp2 docking to the receptor is critical for Src kinase activation, suggesting that Shp2 may contribute to Erk5 activation through its involvement in Src kinase activation
Feng et al., Oncogene 2012 (Disease Progression...) : Furthermore, a dominant negative SHP-2 C459S mutant inhibited PDGF-A stimulated glioma cell migration, phosphorylation of Dyn2 and concomitantly blocked PDGFRa induced Src activation