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E2F1 — IFI27

Text-mined interactions from Literome

Rivard et al., Am J Physiol 1999 : In both cell types, expression of ras resulted in an increase of basal and serum stimulated E2F dependent transcriptional activity and a reduction in p27 ( Kip1 ) protein levels as well
Alexander et al., Mol Cell Biol 2001 : In addition, the use of pRb proteins mutated in the pocket domain demonstrates that pRb upregulation of p27 ( KIP1 ) and senescence induction do not require the interaction of pRb with E2F
Park et al., Carcinogenesis 2001 (Prostatic Neoplasms) : Although expression of E2F-1 was reduced in three prostate cancer cell lines-PC-3, LNCaP and DU-145-the p21 and p27 protein levels were not increased in all the cell lines treated, suggesting that increase in p21 and p27 protein expression per se is not responsible for lovastatin mediated down-regulation of E2F-1
Wang et al., J Biol Chem 2005 : Depletion of endogenous E2F1 by siRNA causes a reduction in basal p27 expression level
Yuan et al., Cancer Res 2007 (Breast Neoplasms...) : In sum, loss of p27 activated AIB1, E2F1 , Gab2, and Akt ; increased cell migration and invasion ; caused antiestrogen insensitivity ; and promoted metastasis of breast cancer cells ... In sum, loss of p27 activated AIB1, E2F1 , Gab2, and Akt ; increased cell migration and invasion ; caused antiestrogen insensitivity ; and promoted metastasis of breast cancer cells