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CD4 — IBD9

Text-mined interactions from Literome

Iijima et al., J Exp Med 1999 (Inflammatory Bowel Diseases) : These findings suggest that IL-4 producing Th2-type CD4 ( + ) betabeta T cells play a major immunopathological role in the induction of IBD in TCR-alpha ( -/- ) mice, a role that anti-IL-4 mAb inhibits by causing Th2-type CD4 ( + ) betabeta T cells to shift to the Th1 type
Trobonjaca et al., J Immunol 2001 (Colitis...) : These data indicate that MHC-II dependent as well as MHC-II independent CD4 ( + ) T cells can induce a severe and lethal IBD in congenic, immunodeficient hosts, but that the former need the latter to express its IBD inducing potential
Uraushihara et al., J Immunol 2003 (Chronic Disease...) : Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid induced TNF receptor family related gene+ regulatory T cells
Maloy et al., J Intern Med 2008 (Inflammatory Bowel Diseases) : The prevailing dogma that IBD was mediated by interleukin (IL)-12-driven T-helper ( Th ) 1 CD4 T cell responses towards the bacterial flora has been largely dispelled by findings that the closely related cytokine IL-23 appears to be the key mediator of intestinal inflammation
Liu et al., Inflamm Bowel Dis 2009 (Inflammatory Bowel Diseases) : IL-21 enhances IBD NK cell cytotoxic response, triggers T cells to produce proinflammatory cytokines, and induces IBD CD4 ( + ) T cells to differentiate into Th17 cells, suggesting that IL-21 is involved in the pathogenesis of IBD and that blocking IL-21R signaling may have a therapeutic potential in IBD