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IFNG — PPARG
Text-mined interactions from Literome
Waite et al., J Biol Chem 2001
(Insulin Resistance) :
Moreover,
IFN-gamma also
inhibited the transcription of
PPARgamma , which was accompanied by a decrease in PPARgamma mRNA accumulation
Von Knethen A et al., FASEB J 2001
:
Delayed
activation of
PPARgamma by LPS and
IFN-gamma attenuates the oxidative burst in macrophages ... Taking the anti-inflammatory properties of the peroxisome proliferator activating receptorgamma ( PPARgamma ) into consideration, we established activation of
PPARgamma in
response to
LPS/IFN-gamma by an electrophoretic mobility shift, supershift, and a reporter gene assay
Floyd et al., J Biol Chem 2002
:
In addition,
IFNgamma treatment
results in the transcriptional activation of
PPARgamma
Alleva et al., J Leukoc Biol 2002
:
Western analysis demonstrated that the antagonistic activity of
IFN-gamma did not
involve modulation of
PPAR-gamma expression but showed that IFN-gamma interfered with PPAR-gamma ligand regulation of p42/p44 MAP kinase activation and the cytosolic disappearance of NF-kappaB upon LPS stimulation
Zhang et al., Blood 2004
:
Overexpression of
PPAR-gamma in PPAR-gamma-null NK cells
reduces IFN-gamma gene expression
Barna et al., Sarcoidosis Vasc Diffuse Lung Dis 2006
(Sarcoidosis, Pulmonary) :
These novel results indicate that
IFN-gamma represses
PPARgamma in human alveolar macrophages but that in sarcoidosis, PPARgamma rather than IFN-gamma levels correlate best with disease severity