Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
EIF2AK1
→
CTNNB1
(increases, CTNNB1 Activity)
Evidence: used siRNAto specifically deplete b-catenin to investigate the potential of accumulated b-catenin to trigger activation of the UPR. Despite treatment with enzastaurin, phosphorylation of eIF2a and induction of CHOP, 2 key markers of the early UPR, were markedly inhibited on depletion of b-catenin (Figure 2D top). Moreover, enzastaurin-induced up-regulation of p21(WAF) was also abrogated on depletion of b-catenin...These findings indicate that enzastaurininduced accumulation of v-catenin activate...