Gene interactions and pathways from curated databases and text-mining

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CDK2 — MAP2K1

Text-mined interactions from Literome

Kivinen et al., Oncogene 1999 (MAP Kinase Signaling System) : p21Cip1/Waf1 cyclin dependent kinase inhibitor ( p21 ) is inducible by Raf and mitogen activated protein kinase kinase ( MAPKK ), but the level of regulation is unknown
Huynh et al., Int J Oncol 2004 (Carcinoma, Hepatocellular...) : Ectopic expression of activated MEK1 in HepG2 cells increased cyclin D1 and Cdk-2 expression, phosphorylation of pRB at Ser780 and Ser795, and percentage of cells in S phase