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CASP3 — MAP2K1
Text-mined interactions from Literome
Shiah et al., Mol Pharmacol 2001
:
Involvement of Asp-Glu-Val-Asp directed,
caspase mediated
mitogen activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel induced apoptosis in HL-60 cells
Johnson et al., Urology 2002
(Prostatic Neoplasms) :
Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage, increases bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt, induces
caspase dependent
mitogen activated protein kinase kinase ( MEK ) cleavage and upregulation of MEK kinase-1, all potential markers of the apoptotic pathway
Nguyen et al., J Cell Physiol 2003
(Lung Neoplasms) :
Inhibition of
MEK1/2 but not PI-3 kinase
blocked kaempferol induced cleavage of
caspase-7 , PARP cleavage, and apoptosis
Nesterov et al., Cancer Res 2004
(Cell Transformation, Neoplastic...) :
The expression of constitutively activated
mitogen activated protein kinase kinase 1
enhanced caspase 8 recruitment and sensitized immortalized human embryonic kidney cells to TRAIL induced death
Zhou et al., Cell Prolif 2007
(MAP Kinase Signaling System) :
The suppression of
MEK1/ERK1/2 activation
inhibited UV-induced expression of c-Fos and JunD and increased
caspase 3 activity and cell death
Zhou et al., Toxicol Appl Pharmacol 2008
:
Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of
caspase-9 , enhanced Bad phosphorylation and
inhibited MEK1/2 , ERK1/2 and JNK phosphorylations
Gao et al., J Appl Physiol 2008
:
Regulation of
caspase-3 activity by insulin in skeletal muscle cells
involves both PI3-kinase and
MEK-1/2 ... Addition of insulin to proteolytically active cells attenuated both responses within 4 h. Individually, inhibitors of either phosphatidylinositide 3-kinase (PI3K) or
MEK1/2 partially
blocked the insulin induced reduction in
caspase-3 activity ; in combination, the inhibitors completely prevented insulin from attenuating caspase-3 activity