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ANGPT1 — MAPK1
Text-mined interactions from Literome
Fujikawa et al., Exp Cell Res 1999
:
In contrast to VEGF mediated biological effects, inhibition of
MAPK/ERKs by PD98059 in endothelial cells did not
affect angiopoietin-1 mediated survival or migration
Zhu et al., Am J Pathol 2002
(MAP Kinase Signaling System) :
Both VEGF and
Ang-1 induced rapid, monophasic ( 15 minutes ) phosphorylation of p38
MAPK
Krikun et al., Am J Pathol 2002
(Uterine Hemorrhage) :
To further examine the effects of progestin, hypoxia, and reactive oxygen species ( ROS ) on the regulation of
Ang-1 and Ang-2 as well as the
activation of
MAPK , SAPK/JNK, and p38 by the relevant cell types, we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs )
Samuel et al., Diabetes 2010
(Diabetes Mellitus, Experimental...) :
We also observed increased phosphorylated
mitogen activated protein kinase activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor ( VEGF ), Flk-1,
angiopoietin-1 (Ang-1) , Tie-2, and survivin, 4 days after treatment in the diabetic animals ... We also observed increased phosphorylated
mitogen activated protein kinase activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor ( VEGF ), Flk-1,
angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals
Babu et al., Infect Immun 2012
(Elephantiasis, Filarial...) :
TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase ( MAPK ) and NF-?B signaling, as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38
MAPK , or NF-?B signaling
resulted in significantly diminished production of VEGF-A and
Ang-1