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PTGS2 — WNT6

Text-mined interactions from Literome

Howe et al., Cancer Res 1999 (Breast Neoplasms...) : In view of the critical role of cyclooxygenase-2 in intestinal tumorigenesis, cyclooxygenase-2 up-regulation in response to Wnt signaling may contribute to Wnt induced mammary carcinogenesis
Rigas et al., Trends Mol Med 2004 (Neoplasms) : Mechanistically, NO-aspirin, the best studied NO-NSAID, has pleiotropic effects on cell signaling ( it inhibits Wnt signaling, induces nitric oxide synthase and NF-kappaB activation and induces cyclooxygenase-2 expression ), and this mechanistic redundancy might be central to its mode of action against cancer
Tuynman et al., Cancer Res 2008 (Colonic Neoplasms) : Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer