◀ Back to SNRPA1
SNRPA — SNRPA1
Pathways - manually collected, often from reviews:
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U4 snRNP/U5 snRNP/U6 snRNP complex ()
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
→
U1 snRNP/U2 snRNP/U4 snRNP/U5 snRNP/U6 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2AF65 (U2AF2)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, activates)
-
BioCarta spliceosomal assembly:
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2 snRNP complex (SNRPA1-SNRPB2)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U1 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, collaborate)
-
BioCarta spliceosomal assembly:
U2AF35 (U2AF1)
→
U1 snRNP/U2 snRNP/pre-mRNA complex (SNRPA-SNRPC-SNRP70-SNRPA1-SNRPB2)
(modification, activates)
-
Reactome Reaction:
SNRPA
→
SNRPA1
(reaction)
Ajuh et al., EMBO J 2000, Jurica et al., RNA 2002, Rappsilber et al., Genome Res 2002, Makarov et al., Science 2002, Hartmuth et al., Proc Natl Acad Sci U S A 2002, Behzadnia et al., EMBO J 2007, Neubauer et al., Nat Genet 1998
-
Reactome Reaction:
SNRPA
→
SNRPA1
(indirect_complex)
Ajuh et al., EMBO J 2000, Rappsilber et al., Genome Res 2002, Hartmuth et al., Proc Natl Acad Sci U S A 2002, Behzadnia et al., EMBO J 2007, Neubauer et al., Nat Genet 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SNRPA
—
SNRPA1
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
SNRPA
—
SNRPA1
(direct interaction, two hybrid)
Hegele et al., Mol Cell 2012
-
MIPS CORUM CDC5L complex:
CDC5L complex complex (BCAS2-BZW1-CDC5L-CWC15-DYNC1H1-GCN1L1-HSPA8-ILF2-PLRG1-PPM1D-PPP1CA-PRKDC-PRPF19-SCAF8-RBMX-SF3B1-SF3B2-SF3B4-SFI1-SFPQ-SRSF1-SRSF2-SNRPA-SNRPA1-SNRPD1-SNRPD2-SNRPD3-SRRM1-TCF4-TOP2A)
Ajuh et al., EMBO J 2000
-
MIPS CORUM Spliceosome:
Spliceosome complex (ACIN1-AQR-DDX39B-BCAS2-BUD13-BUD31-CFAP20-CACTIN-C19orf43-CD2BP2-CDC40-CDC5L-CIRBP-CPSF6-CDK12-CRNKL1-LUC7L3-CTNNBL1-CWC15-CWC22-DDX17-DDX23-DDX3X-DDX41-DDX46-DDX5-DGCR14-DHX15-DHX16-DHX38-DHX8-DHX9-DNAJC8-EFTUD2-EIF4A3-PAXBP1-HTATSF1-IGF2BP3-IK-ISY1-KIAA1429-LSM2-LSM3-LSM4-LSM6-LSM7-MAGOH-MFAP1-MOV10-NCBP1-NCBP2-NHP2L1-NUDT21-PABPC1-PLRG1-PPIE-PPIH-PPIL1-PPIL2-PPIL3-PPM1G-PPWD1-PRPF18-PRPF19-PRPF3-PRPF31-PRPF4-PRPF40A-PRPF4B-PRPF6-PRPF8-PUF60-RBM15-RBM17-RBM22-RBM25-RBM39-RBM8A-RNPS1-SART1-SF1-SF3A1-SF3A2-SF3A3-SF3B1-SF3B6-SF3B2-SF3B3-SF3B4-SRSF1-SRSF11-SRSF2-SRSF3-SRSF4-SRSF5-SRSF7-SKIV2L2-SLU7-SMNDC1-SMU1-SNRNP200-SNRNP27-SNRNP40-SNRNP70-SNRPA-SNRPA1-SNRPB-SNRPB2-SNRPC-SNRPD1-SNRPD2-SNRPD3-SNRPE-SNRPF-SNRPG-SNW1-SPEN-U2SURP-SRRM1-SRRM2-SRRT-SRSF6-SRSF9-SYF2-TCERG1-TFIP11-THOC1-THOC2-THOC3-ALYREF-THOC5-THOC6-THOC7-TRA2B-TXNL4A-U2AF1-U2AF2-USP39-WBP11-WTAP-XAB2-ZNF207)
Zhou et al., Nature 2002
-
IRef Corum Interaction:
Complex of 61 proteins
(association, coimmunoprecipitation)
Ajuh et al., EMBO J 2000
-
IRef Corum Interaction:
Complex of 427 proteins
(association, molecular sieving)
Zhou et al., Nature 2002
-
IRef Intact Interaction:
SNRPA
—
SNRPA1
(physical association, two hybrid)
Hegele et al., Mol Cell 2012
-
IRef Intact Interaction:
Complex of 30 proteins
(association, anti tag coimmunoprecipitation)
Pichlmair et al., Nat Immunol 2011
-
IRef Intact Interaction:
Complex of 33 proteins
(association, anti tag coimmunoprecipitation)
Pichlmair et al., Nat Immunol 2011
-
IRef Intact Interaction:
Complex of 36 proteins
(association, anti tag coimmunoprecipitation)
Pichlmair et al., Nat Immunol 2011
Text-mined interactions from Literome
Daugeron et al., Nucleic Acids Res 1992
:
Moreover, RNAse T1 protection coupled to immunoprecipitation experiments have demonstrated that only the 5 ' end sequence of U1 snRNA contacts the consensus 5 ' splice site containing RNA, arguing that
U2 snRNP binding in the tripartite complex is
mediated by
U1 snRNP
Fu et al., Proc Natl Acad Sci U S A 1992
:
Significantly, the SC35 dependent interaction between
U1 snRNP and the 3 ' splice site
requires U2 snRNP but not the 5 ' splice site
Gräub et al., Cell cycle (Georgetown, Tex.) 2008
:
We also demonstrate that a specific inhibitor of
CDK2 , CVT-313,
inhibits CDC5L phosphorylation in both in vitro kinase assays and in vivo radiolabeling experiments in cycling cells
Martins de Araújo et al., RNA 2009
(Muscular Atrophy, Spinal) :
Two trans acting factors implicated in
SMN regulation , SF2/ASF and hnRNP A1, promote and repress, respectively,
U2 snRNP recruitment to both RNAs
Urano-Tashiro et al., J Neurosci Res 2010
:
Implication of
Akt dependent Prp19
alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation ... Here, we demonstrated that PRP19
alpha/14-3-3beta/CDC5L complex formation is
regulated by
Akt during nerve growth factor (NGF) induced neuronal differentiation of PC12 cells
Blencowe et al., Genes Dev 1998
(Lymphoma, Large B-Cell, Diffuse) :
Binding of
SRm160/300 to pre-mRNA is normally also
dependent on
U1 snRNP and is stabilized by U2 snRNP