UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to CBL

CBL — CD3E

Pathways - manually collected, often from reviews:

NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL) (modification, collaborate)
Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → CBL (CBL) (modification, collaborate) Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL) → CBL (CBL) (modification, collaborate) Rao et al., Proc Natl Acad Sci U S A 2002
Evidence: assay
NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: CBL (CBL) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD8+ T cells: TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) → TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL) (modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → CBL (CBL) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → SLAP-2 (SLA2) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction
NCI Pathway Database TCR signaling in naïve CD4+ T cells: CBL (CBL) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
Evidence: assay, physical interaction