Klampfer et al., J Biol Chem 2004
(Inflammation) :
In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1 dependent gene activation
Ivanov et al., Oncogene 2007
:
Involvement of HDAC activity in STAT1 regulation was validated by TSA inhibition and chromatin immunoprecipitation ( ChIP ) assay