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HSP90AA1 — ILK

Pathways - manually collected, often from reviews:

• NCI Pathway Database Integrin-linked kinase signaling: ILK/HSP90/CDC37 complex (ILK) → Hsp90 (HSP90AA1) (modification, collaborate) Aoyagi et al., Biochem Biophys Res Commun 2005*
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: Hsp90 (HSP90AA1) → ILK (ILK) (modification, collaborate) Aoyagi et al., Biochem Biophys Res Commun 2005*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ILK — HSP90AA1 (physical association, affinity chromatography technology) Taipale et al., Cell 2012
• IRef Biogrid Interaction: ILK — HSP90AA1 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Aoyagi et al., Biochem Biophys Res Commun 2005 : ILK was identified as a new Hsp90 client protein because it formed a complex with Hsp90 and Cdc37, and binding was suppressed by Hsp90 inhibitors ... These results indicate that Hsp90 plays an important role in the stability of ILK in cells
Radovanac et al., EMBO J 2013 (Fibrosis) : The chaperone Hsp90 stabilizes ILK and facilitates the interaction of ILK with a-parvin ... Together, our results uncover how Hsp90 regulates ILK stability and identify a potential therapeutic strategy to alleviate fibrotic diseases