Gene interactions and pathways from curated databases and text-mining

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IGF1 — PTTG1

Text-mined interactions from Literome

Chamaon et al., Biochem Biophys Res Commun 2005 (Astrocytoma) : Regulation of the pituitary tumor transforming gene by insulin-like-growth factor-I and insulin differs between malignant and non-neoplastic astrocytes
Chamaon et al., Exp Clin Endocrinol Diabetes 2010 (Adenoma...) : Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells
Chesnokova et al., Mol Endocrinol 2012 (Chromosomal Instability...) : FOXL2 directly stimulates the Clu gene promoter, and we show that PTTG triggers ataxia telangiectasia mutated kinase/IGF-I/p38MAPK DNA damage/chromosomal instability signaling, which in turn also induces Clu expression