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CREB1 — IFNG
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hamada et al., Toxicology 2000
:
However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with
rMu-IFN-gamma + Be
increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of AP-1 and
CREB at 15 h, however, only Jun B was increased
Samten et al., J Immunol 2002
(Tuberculosis) :
These data suggest that reduced expression of
CREB nuclear proteins in tuberculosis patients
results in decreased
IFN-gamma promoter activity and reduced IFN-gamma production
Frissora et al., Eur J Immunol 2003
:
IFN-gamma mediated inhibition of antigen receptor induced B cell proliferation and
CREB-1 binding activity requires STAT-1 transcription factor ... Recombinant
IFN-gamma inhibited the BCR induced
CREB-1 DNA binding activity and cell proliferation in B cells from signal transducer and activator of transcription-1 ( STAT-1 ) ( +/+ ), but not STAT-1 ( -/- ) mice
Liu et al., J Interferon Cytokine Res 2004
:
Moreover,
IFN-gamma stimulated CREB phosphorylation and
CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89
Sheu et al., Food Chem Toxicol 2006
(Glomerulonephritis) :
Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein (
CREB )
induced by
LPS/IFN-gamma
Hu et al., Immunity 2006
(Arthritis...) :
IFN-gamma suppressed the activity of
CREB and AP-1, transcription factors that induce IL-10 expression and are regulated in part by MAPKs and GSK3
Chiappara et al., Allergy 2007
(Asthma...) :
Incubation of PBMC in vitro, with fluticasone propionate, decreased the
p-CREB expression
induced by cytokine activation (
interferon-gamma , tumor necrosis factor-alpha )
Gilchrist et al., Immunology 2008
:
IFN-gamma inhibited PMA induced cAMP response element binding protein (
CREB ) phosphorylation and DNA binding activity
Kim et al., J Leukoc Biol 2008
:
IFN-gamma caused phosphorylation of CREB, and overexpression of
CREB increased IFN-gamma induced BAFF promoter activity
Samten et al., J Immunol 2008
:
CREB , ATF, and AP-1 transcription factors
regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
Liu et al., Clinical and vaccine immunology : CVI 2010
(Latent Tuberculosis) :
These results suggested that
CREB could
promote the transcription and production of
IFN-gamma through binding with the IFN-gamma proximal promoter, but the regulatory role of CREB was decreased in tuberculosis patients owing to diminished expression of CREB proteins, which in turn reduced the IFN-gamma production